H
Hironori Suzuki
Researcher at University of Canterbury
Publications - 12
Citations - 735
Hironori Suzuki is an academic researcher from University of Canterbury. The author has contributed to research in topics: Escherichia coli & Autophagy. The author has an hindex of 7, co-authored 12 publications receiving 579 citations. Previous affiliations of Hironori Suzuki include KEK.
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Journal ArticleDOI
PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins.
David G. McEwan,Doris Popovic,Andrea Gubas,Seigo Terawaki,Seigo Terawaki,Seigo Terawaki,Hironori Suzuki,Daniela Stadel,Fraser P. Coxon,Diana Miranda de Stegmann,Sagar Bhogaraju,Karthik Maddi,Anja Kirchof,Evelina Gatti,Evelina Gatti,Evelina Gatti,Miep H. Helfrich,Soichi Wakatsuki,Christian Behrends,Philippe Pierre,Philippe Pierre,Philippe Pierre,Ivan Dikic,Ivan Dikic +23 more
TL;DR: Pleckstrin homology domain containing protein family member 1 (PLEKHM1) directly interacts with HOPS complex and contains a LC3-interacting region (LIR) that mediates its binding to autophagosomal membranes.
Journal ArticleDOI
Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins.
Vladimir V. Rogov,Hironori Suzuki,Mija Marinković,Verena Lang,Ryuichi Kato,Masato Kawasaki,Maja Buljubašić,Matilda Šprung,Natalia Yu. Rogova,Soichi Wakatsuki,Anne Hamacher-Brady,Anne Hamacher-Brady,Volker Dötsch,Ivan Dikic,Ivan Dikic,Nathan R. Brady,Ivana Novak,Ivana Novak +17 more
TL;DR: Evidence is provided that phosphorylation of the LIR domain of Nix enhances mitophagy receptor engagement and enhances autophagosome recruitment to mitochondria in HeLa cells.
Journal ArticleDOI
Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.
Hironori Suzuki,Hironori Suzuki,Keisuke Tabata,Eiji Morita,Masato Kawasaki,Ryuichi Kato,Renwick C. J. Dobson,Renwick C. J. Dobson,Tamotsu Yoshimori,Soichi Wakatsuki +9 more
TL;DR: Structural and binding analyses reveal that the side-chain of Lys49 of LC3 acts as a gatekeeper to regulate binding of the LIR, suggesting that specific affinity of the LC3 isoforms to the Atg13 LIR is required for proper autophagosome formation.
Journal ArticleDOI
Ultra-high resolution crystal structure of recombinant caprine β-lactoglobulin.
Jennifer M. Crowther,Moritz Lassé,Hironori Suzuki,Sarah A. Kessans,Trevor S. Loo,Gillian E. Norris,Alison J. Hodgkinson,Geoffrey B. Jameson,Renwick C. J. Dobson +8 more
TL;DR: An ultra‐high resolution crystal structure of caprine βlg complemented by analytical ultracentrifugation and small‐angle X‐ray scattering data suggests a flexible quaternary arrangement of subunits within the dimer.
Journal ArticleDOI
Differential response of orthologous l,l-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds
Shaun M. K. McKinnie,Eva M. Rodriguez-Lopez,John C. Vederas,Jennifer M. Crowther,Hironori Suzuki,Renwick C. J. Dobson,Thomas Leustek,Alexander J. Triassi,Matthew S. Wheatley,André O. Hudson +9 more
TL;DR: It is concluded that the altered binding patterns seen in the inhibition studies may be a consequence of the inhibitors forming additional interactions with residues proximal to the active site, or that the inhibitors may not act by binding to theactive site.