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Open AccessJournal ArticleDOI

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins.

David G. McEwan, +23 more
- 08 Jan 2015 - 
- Vol. 57, Iss: 1, pp 39-54
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TLDR
Pleckstrin homology domain containing protein family member 1 (PLEKHM1) directly interacts with HOPS complex and contains a LC3-interacting region (LIR) that mediates its binding to autophagosomal membranes.
About: 
This article is published in Molecular Cell.The article was published on 2015-01-08 and is currently open access. It has received 412 citations till now. The article focuses on the topics: Endosome & Autophagy.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Mechanism and medical implications of mammalian autophagy

Ivan Dikic, +1 more
- 01 Jun 2018 - 
TL;DR: It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Molecular definitions of autophagy and related processes

Lorenzo Galluzzi, +62 more
- 03 Jul 2017 - 
TL;DR: A panel of leading experts in the field attempts here to define several autophagy‐related terms based on specific biochemical features to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagic research.
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Autophagy pathway: Cellular and molecular mechanisms

Li Yu, +2 more
- 01 Jan 2018 - 
TL;DR: This review will define this process and the cellular pathways required, from the formation of the double membrane to the fusion with lysosomes in molecular terms, and in particular highlight the recent progress in understanding of this complex process.
References
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Andrew M. Waterhouse, +4 more
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, +12 more
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TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
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Marino Zerial, +1 more
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Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, +12 more
- 15 Jun 2006 - 
TL;DR: It is found that mice lacking Atg7 specifically in the central nervous system showed behavioural defects, including abnormal limb-clasping reflexes and a reduction in coordinated movement, and died within 28 weeks of birth, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies.
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Rab GTPases as coordinators of vesicle traffic.

Harald Stenmark
- 01 Aug 2009 - 
TL;DR: Crosstalk between multiple Rab GTPases through shared effectors, or through effectors that recruit selective Rab activators, ensures the spatiotemporal regulation of vesicle traffic.
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