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Andrea Gubas
Researcher at Goethe University Frankfurt
Publications - 12
Citations - 850
Andrea Gubas is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Autophagy & Lysosome. The author has an hindex of 6, co-authored 10 publications receiving 573 citations. Previous affiliations of Andrea Gubas include Francis Crick Institute.
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Journal ArticleDOI
PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins.
David G. McEwan,Doris Popovic,Andrea Gubas,Seigo Terawaki,Seigo Terawaki,Seigo Terawaki,Hironori Suzuki,Daniela Stadel,Fraser P. Coxon,Diana Miranda de Stegmann,Sagar Bhogaraju,Karthik Maddi,Anja Kirchof,Evelina Gatti,Evelina Gatti,Evelina Gatti,Miep H. Helfrich,Soichi Wakatsuki,Christian Behrends,Philippe Pierre,Philippe Pierre,Philippe Pierre,Ivan Dikic,Ivan Dikic +23 more
TL;DR: Pleckstrin homology domain containing protein family member 1 (PLEKHM1) directly interacts with HOPS complex and contains a LC3-interacting region (LIR) that mediates its binding to autophagosomal membranes.
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A molecular perspective of mammalian autophagosome biogenesis
TL;DR: The function and regulation of ULK and VPS34 kinase complexes, phosphatidylinositol 3-phosphate effector proteins, and the transmembrane autophagy-related protein ATG9 will be addressed, in particular during amino acid starvation.
Journal ArticleDOI
A guide to the regulation of selective autophagy receptors.
TL;DR: This work highlights the four most prominent protein modifications – phosphorylation, ubiquitination, acetylation and oligomerisation – that are essential for autophagy receptor recruitment, function and turnover.
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Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
TL;DR: A significant decrease in the rate of constitutive autophagy biogenesis during aging is identified and pronounced morphological defects in autophagosomes in neurons from aged mice are observed, suggesting a novel therapeutic target in age-associated neurodegeneration.
Journal ArticleDOI
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation.
Guang Lu,Juan Yi,Andrea Gubas,Ya-Ting Wang,Yihua Wu,Yi Ren,Man Wu,Man Wu,Yin Shi,Yin Shi,Chenxi Ouyang,Hayden Weng Siong Tan,Tianru Wang,Liming Wang,Nai-Di Yang,Shuo Deng,Dajing Xia,Ruey-Hwa Chen,Sharon A. Tooze,Han-Ming Shen +19 more
TL;DR: This study discovers a novel function of CRL4s in autophagy by targeting WIPI2 for polyubiquitination and proteasomal degradation during mitosis.