Hiroyuki Okuda

TL;DR: Gene transfer-mediated overexpression of Bcl-2 or BAG-1 led to prolonged cell survival of MKN74 cells against serum-starved apoptosis and anoikis, demonstrating that resistance to apoptosis is a crucial factor for development of peritoneal dissemination of human gastric cancer cells.

TL;DR: On the basis of a retrospective study of patients who underwent endoscopic resection for T1 CRC, those with tumors with only submucosal invasion are at low risk for cancer recurrence, however, patients with other high-risk tumor features have greater risks forcancer recurrence and benefit from subsequent surgery.

TL;DR: In this paper, the authors identify a relationship between specific miRNA molecules and BRAF mutation in colorectal cancers and serrated lesions and demonstrate that miR-31 inhibitor decreased cell invasion and proliferation.

TL;DR: Second‐line FOLFIRI plus panitumumab and FOL FIRI plus bevacizumab showed a similar efficacy in patients with WT KRAS exon 2 mCRC and RAS and BRAF mutation in ctDNA could be a negative predictive marker for panitUMumab.

TL;DR: High miR-31-5p expression was associated with shorter PFS in patients with CRC treated with anti-EGFR therapeutics, suggesting that it may be a useful and additional prognostic biomarker for anti- EGFR therapy.