K
Kei Mitsuhashi
Researcher at Sapporo Medical University
Publications - 24
Citations - 1058
Kei Mitsuhashi is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 11, co-authored 24 publications receiving 796 citations.
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Journal ArticleDOI
Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis
Kei Mitsuhashi,Katsuhiko Nosho,Yasutaka Sukawa,Yasutaka Matsunaga,Miki Ito,Hiroyoshi Kurihara,Shinichi Kanno,Hisayoshi Igarashi,Takafumi Naito,Yasushi Adachi,Mami Tachibana,Tokuma Tanuma,Hiroyuki Maguchi,Toshiya Shinohara,Tadashi Hasegawa,Masafumi Imamura,Yasutoshi Kimura,Koichi Hirata,Reo Maruyama,Hiromu Suzuki,Kohzoh Imai,Hiroyuki Yamamoto,Yasuhisa Shinomura +22 more
TL;DR: Tumor Fusobacterium species status is independently associated with a worse prognosis of pancreatic cancer, suggesting that FusOBacterium Species may be a prognostic biomarker of pancreatIC cancer.
Journal ArticleDOI
Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer
Katsuhiko Nosho,Yasutaka Sukawa,Yasushi Adachi,Miki Ito,Kei Mitsuhashi,Hiroyoshi Kurihara,Shinichi Kanno,Itaru Yamamoto,Keisuke Ishigami,Hisayoshi Igarashi,Reo Maruyama,Kohzoh Imai,Hiroyuki Yamamoto,Yasuhisa Shinomura +13 more
TL;DR: Emerging evidence may provide insights for strategies to target microbiota, immune cells and tumor molecular alterations for colorectal cancer prevention and treatment.
Journal ArticleDOI
Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway
Miki Ito,Shinichi Kanno,Katsuhiko Nosho,Yasutaka Sukawa,Kei Mitsuhashi,Hiroyoshi Kurihara,Hisayoshi Igarashi,Taiga Takahashi,Mami Tachibana,Hiroaki Takahashi,Shinji Yoshii,Toshinao Takenouchi,Tadashi Hasegawa,Kenji Okita,Koichi Hirata,Reo Maruyama,Hiromu Suzuki,Kohzoh Imai,Hiroyuki Yamamoto,Yasuhisa Shinomura +19 more
TL;DR: The presence of F. nucleatum was identified in premalignant colorectal lesions regardless of histopathology but was more frequently associated with CIMP‐high lesions, and its positivity increased according to histological grade, suggesting that it may contribute to the progression of coloreCTal neoplasia.
Journal ArticleDOI
HER2 expression and PI3K-Akt pathway alterations in gastric cancer.
Yasutaka Sukawa,Hiroyuki Yamamoto,Katsuhiko Nosho,Miki Ito,Hisayoshi Igarashi,Takafumi Naito,Kei Mitsuhashi,Yasutaka Matsunaga,Taiga Takahashi,Masashi Mikami,Yasushi Adachi,Hiromu Suzuki,Yasuhisa Shinomura +12 more
TL;DR: It is found that HER2 over-expression was significantly correlated with pAkt expression in GC tissues and pAKT expression was correlated with poor prognosis, suggesting that the PI3K-Akt pathway plays an important role in HER2-positive GC.
Journal ArticleDOI
Association of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer
Hisayoshi Igarashi,Hiroyoshi Kurihara,Kei Mitsuhashi,Miki Ito,Hiroyuki Okuda,Shinichi Kanno,Takafumi Naito,Shinji Yoshii,Hiroaki Takahashi,Takaya Kusumi,Tadashi Hasegawa,Yasutaka Sukawa,Yasutaka Sukawa,Yasushi Adachi,Kenji Okita,Koichi Hirata,Yu Imamura,Yoshifumi Baba,Kohzoh Imai,Hiromu Suzuki,Hiroyuki Yamamoto,Katsuhiko Nosho,Yasuhisa Shinomura +22 more
TL;DR: High miR-31-5p expression was associated with shorter PFS in patients with CRC treated with anti-EGFR therapeutics, suggesting that it may be a useful and additional prognostic biomarker for anti- EGFR therapy.