Hong-Erh Liang

TL;DR: Tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice, and it is shown that endogenous, tissue-derived signals drive the maturation of I LC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life.

TL;DR: A metabolic sensing circuit that may have evolved to facilitate mutualistic responses to luminal pathosymbionts is described that impairs infestation by new helminths, consistent with the phenomenon of concomitant immunity.

TL;DR: The contribution of basophils to allergic and helminth immunity remains unclear as discussed by the authors, and Locksley et al. used reporter strains and two-photon microscopy to demonstrate that basophilia does not mediate T helper type 2 priming in vivo.

TL;DR: Infection with the helminth Nippostrongylus brasiliensis resulted in diminished effector cell recruitment and impaired worm expulsion, demonstrating that TML cells are not sufficient to mediate an effective immune response.

TL;DR: Inhaled chitin elicited patterns of innate cytokines that targeted distinct populations of resident lymphoid cells, revealing divergent but interacting pathways underlying the tissue accumulation of specific types of inflammatory myeloid cells.