H
Hongmei Li
Researcher at Chinese Academy of Sciences
Publications - 111
Citations - 6143
Hongmei Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: China & Amyloid precursor protein. The author has an hindex of 39, co-authored 91 publications receiving 5323 citations. Previous affiliations of Hongmei Li include University of Pennsylvania & Georgia State University.
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Journal ArticleDOI
An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore
Kambiz N. Alavian,Gisela Beutner,Emma Lazrove,Silvio Sacchetti,Han-A Park,Pawel Licznerski,Hongmei Li,Panah Nabili,Kathryn Hockensmith,Morven Graham,George A. Porter,Elizabeth A. Jonas +11 more
TL;DR: It is shown that the purified reconstituted c-subunit ring of the FO of the F1FO ATP synthase forms a voltage-sensitive channel, the persistent opening of which leads to PT and cell death, and implies that increasing the probability of c- subunit channel closure in a healthy cell will enhance IMM coupling and increase cellular metabolic efficiency.
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2D Differential In-gel Electrophoresis for the Identification of Esophageal Scans Cell Cancer-specific Protein Markers
Ge Zhou,Hongmei Li,Dianne L. DeCamp,She Chen,Hongjun Shu,Yi Gong,Michael J. Flaig,John W. Gillespie,Nan Hu,Philip R. Taylor,Michael R. Emmert-Buck,Lance A. Liotta,Emanuel F. Petricoin,Yingming Zhao +13 more
TL;DR: Global quantification of protein expression between laser capture microdissection-microdissected patient-matched cancer cells and normal cells using 2D DIGE in combination with mass spectrometry is a powerful tool for the molecular characterization of cancer progression and identification of cancer-specific protein markers.
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Ex vivo red blood cell hemolysis assay for the evaluation of pH-responsive endosomolytic agents for cytosolic delivery of biomacromolecular drugs.
Brian C. Evans,Christopher E. Nelson,Shann S. Yu,Kelsey R. Beavers,Arnold J. Kim,Hongmei Li,Heather M. Nelson,Todd D. Giorgio,Craig L. Duvall +8 more
TL;DR: The hemolysis assay is described, which can be used as rapid, high-throughput screen for the cytocompatibility and endosomolytic activity of intracellular drug delivery systems.
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Demand for rubber is causing the loss of high diversity rain forest in SW China
TL;DR: In this article, the authors focus on how changing economic dynamics are influencing land-use and land-cover change in Xishuangbanna, China, focusing on how increasing demand for natural rubber and the expansion of rubber plantations is threatening this high-diversity region.
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Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
Vinicia Assunta Polito,Hongmei Li,Heidi Martini-Stoica,Baiping Wang,Li Yang,Yin Xu,Dan B. Swartzlander,Michela Palmieri,Michela Palmieri,Alberto di Ronza,Alberto di Ronza,Virginia M.-Y. Lee,Marco Sardiello,Marco Sardiello,Andrea Ballabio,Andrea Ballabio,Hui Zheng +16 more
TL;DR: It is demonstrated that TFEB effectively reduces neurofibrillary tangle pathology and rescues behavioral and synaptic deficits and neurodegeneration in the rTg4510 mouse model of tauopathy with no detectable adverse effects when expressed in wild‐type mice.