Hongshan Zhang

TL;DR: It is shown that in the presence of the NIPBLMAU2 protein complex, the human cohesin complex can function as a molecular motor that extrudes DNA loops with high speed in vitro and compacts DNA in an ATP-dependent manner.

TL;DR: Observations suggest that XRCC4–XLF complexes form mobile sleeve-like structures around DNA that can reconnect the broken ends very rapidly and hold them together, which will lead to clarification of how NHEJ proteins are involved in generating chromosomal translocations.

TL;DR: In this paper, the photoassociative formation of RbCs molecules in the excited state correlated to the vibrational level was investigated in detail, and the rotational constant and centrifugal distortion constant were derived to be 0.01304 cm and 0.000015 cm, respectively.

TL;DR: RAD52 binding changes the nature of the overstretching transition of dsDNA and prevents DNA melting, which is advantageous for strand clamping during or after annealing, and may help key steps in DNA repair.

TL;DR: Low-complexity ssDNA curtains are developed and characterize, a high-throughput single-molecule assay to simultaneously monitor protein binding and correlated ssDNA length changes on supported lipid bilayers is developed, and results indicate that RPA-ssDNA interactions are not significantly altered by these modifications.