Hongying Li

TL;DR: It is found that alpha-CoVs have switched hosts more frequently than betaCoVs, and a bat family and genus that are highly involved in host-switching are identified, which define hotspots of CoV evolutionary diversity.

TL;DR: The results expand the understanding of the viromes of rodents and insectivores in China and suggest that there is high diversity of viruses awaiting discovery in these species in Asia.

TL;DR: It is found that host-switching was more frequent and across more distantly related host taxa in alpha-than beta-CoVs, and more highly constrained by phylogenetic distance for beta- coV, and it is shown that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolia.

TL;DR: To prevent the next epidemic and pandemic related to these interfaces, it is called for research and investment in three areas: surveillance among wildlife to identify the high-risk pathogens they carry, surveillance among people who have contact with wildlife, and improvement of market biosecurity regarding the wildlife trade.

TL;DR: The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event, which can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence.