Hugo M. Horlings

TL;DR: It is shown here that PTEN depletion abrogates BRAF(V600E)-induced senescence in human fibroblasts and melanocytes, and demonstrated that PI3K pathway activation serves as a rate-limiting event in this setting, acting at least in part by abrogating OIS.

TL;DR: This method shows that the wound response signature, a poor-prognosis expression pattern of 512 genes in breast cancer, is induced by coordinate amplifications of MYC and CSN5 (also known as JAB1 or COPS5).

TL;DR: Supported by the recent evidence of the presence of B miyamotoi in Ixodes ricinus ticks across Europe, the relation in time of the patient’s symptoms with the tick bites, and his immunocompromised status, the patient was treated for a possible Lyme neuroborreliosis with once daily 2000 mg ceftriaxone intravenously for 2 weeks and fully recovered.

TL;DR: In a study in patients with advanced BRAF+MEK inhibitor-resistant melanoma, vorinostat can selectively ablate drug-resistant tumor cells, providing clinical proof of concept for the novel therapy identified here.

TL;DR: This work establishes the potency of the somatic genome, reflective of diverse DNA repair deficiencies, to stratify ovarian cancers into distinct biological strata within the major histotypes.