H
Hui-Leen Tan
Researcher at Royal Perth Hospital
Publications - 14
Citations - 1293
Hui-Leen Tan is an academic researcher from Royal Perth Hospital. The author has contributed to research in topics: Methicillin-resistant Staphylococcus aureus & SCCmec. The author has an hindex of 11, co-authored 13 publications receiving 1175 citations. Previous affiliations of Hui-Leen Tan include Curtin University.
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Journal ArticleDOI
A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
Stefan Monecke,Geoffrey W. Coombs,Anna C. Shore,David C. Coleman,Patrick Eberechi Akpaka,Michael Borg,Henry Chow,Margaret Ip,Lutz Jatzwauk,Daniel Jonas,Kristina Kadlec,Angela M. Kearns,Frédéric Laurent,Frances G. O'Brien,Julie C. Pearson,Antje Ruppelt,Stefan Schwarz,E. Scicluna,Peter Slickers,Hui-Leen Tan,Stefan Weber,Ralf Ehricht +21 more
TL;DR: A high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements is shown, and the data indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements.
Journal ArticleDOI
Community-acquired pneumonia due to pandemic A(H1N1)2009 influenzavirus and methicillin resistant Staphylococcus aureus co-infection
Ronan J. Murray,James O. Robinson,Jodi N. White,Frank Hughes,Geoffrey W. Coombs,Julie C. Pearson,Hui-Leen Tan,Glenys Chidlow,Simon H. Williams,Keryn J. Christiansen,David Smith +10 more
TL;DR: Clinicians managing patients with pandemic A(H1N1)2009 influenzavirus infection should be alert to the possibility of co-infection or sequential infection with virulent, antimicrobial-resistant bacterial pathogens such as cMRSA.
Journal ArticleDOI
Evolution and diversity of community-associated methicillin-resistant Staphylococcus aureus in a geographical region
Geoffrey W. Coombs,Geoffrey W. Coombs,Stefan Monecke,Julie C. Pearson,Hui-Leen Tan,Yi-Kong Chew,Lynne Wilson,Ralf Ehricht,Frances G. O'Brien,Keryn J. Christiansen,Keryn J. Christiansen +10 more
TL;DR: Data suggest the successful evolution of a CA-MRSA clone may not only depend on the mobility of the SCCmec element but also on other genetic determinants.
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Differentiation of Clonal Complex 59 Community-Associated Methicillin-Resistant Staphylococcus aureus in Western Australia
Geoffrey W. Coombs,Geoffrey W. Coombs,Stefan Monecke,Ralf Ehricht,Peter Slickers,Julie C. Pearson,Hui-Leen Tan,Keryn J. Christiansen,Keryn J. Christiansen,Frances G. O'Brien +9 more
TL;DR: The differentiation of CC59 into groups and strains indicates a rapid evolution and spread of SCCmec elements.
Journal ArticleDOI
Genetic and Molecular Predictors of High Vancomycin MIC in Staphylococcus aureus Bacteremia Isolates
Natasha E Holmes,John D Turnidge,John D Turnidge,Wendy J. Munckhof,Wendy J. Munckhof,J. Owen Robinson,J. Owen Robinson,Tony M. Korman,Matthew V. N. O'Sullivan,Matthew V. N. O'Sullivan,Tara L. Anderson,Tara L. Anderson,Sally Roberts,Sanchia J C Warren,Sanchia J C Warren,Geoffrey W. Coombs,Geoffrey W. Coombs,Hui-Leen Tan,Hui-Leen Tan,Wei Gao,Paul D R Johnson,Paul D R Johnson,Benjamin P Howden +22 more
TL;DR: Data suggest that inherent organism characteristics may explain the link between elevated vancomycin MICs and poor outcomes in patients with SAB, regardless of the antibiotic treatment received, and should be included in future research when attempting to ascertain treatment effects or clinical outcomes.