H
Hyo Sang Lee
Researcher at Oregon National Primate Research Center
Publications - 7
Citations - 1375
Hyo Sang Lee is an academic researcher from Oregon National Primate Research Center. The author has contributed to research in topics: Embryonic stem cell & Embryoid body. The author has an hindex of 7, co-authored 7 publications receiving 1283 citations. Previous affiliations of Hyo Sang Lee include Oregon Health & Science University.
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Journal ArticleDOI
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
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Towards germline gene therapy of inherited mitochondrial diseases
Masahito Tachibana,Paula Amato,Michelle Sparman,Joy Woodward,Dario Melguizo Sanchis,Hong Ma,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Eunju Kang,Hyo Sang Lee,Cathy Ramsey,Keith Masterson,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Shoukhrat Mitalipov,Shoukhrat Mitalipov +22 more
TL;DR: Although some ST oocytes displayed abnormal fertilization, remaining embryos were capable of developing to blastocysts and producing embryonic stem cells similar to controls.
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Generation of Chimeric Rhesus Monkeys
Masahito Tachibana,Michelle Sparman,Cathy Ramsey,Hong Ma,Hyo Sang Lee,Maria Cecilia T. Penedo,Shoukhrat Mitalipov,Shoukhrat Mitalipov +7 more
TL;DR: It is demonstrated that rhesus monkey embryonic stem cells and isolated ICMs fail to incorporate into host embryos and develop into chimeras, and it is suggested that a chimera assay using pluripotent cells may not be feasible.
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Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck
Hyo Sang Lee,Hong Ma,Rita Cervera Juanes,Masahito Tachibana,Michelle Sparman,Joy Woodward,Cathy Ramsey,Jing Xu,Eun Ju Kang,Paula Amato,Georg Mair,Ralf Steinborn,Shoukhrat Mitalipov +12 more
TL;DR: Evidence is presented for a previously unknown mtDNA segregation and bottleneck during preimplantation embryo development, suggesting that return to the homoplasmic condition can occur during development of an individual organism from the zygote to birth, without a passage through the germline.
Journal ArticleDOI
Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.
Jo Ann Janovick,Jo Ann Janovick,M. David Stewart,M. David Stewart,Darla Jacob,L. D. Martin,Jian Min Deng,C. Allison Stewart,Ying Wang,Anda Cornea,Lakshmi Chavali,Suhujey Lopez,Shoukhrat Mitalipov,Eunju Kang,Hyo Sang Lee,Pulak R. Manna,Douglas M. Stocco,Richard R. Behringer,P. Michael Conn,P. Michael Conn +19 more
TL;DR: Pulsatile pharmacoperone therapy restores E90K from ER retention to the plasma membrane, concurrently with responsiveness to the endogenous natural ligand, gonadotropin releasing hormone, and an agonist that is specific for the mutant.