E
Eunju Kang
Researcher at University of Ulsan
Publications - 62
Citations - 4019
Eunju Kang is an academic researcher from University of Ulsan. The author has contributed to research in topics: Mitochondrial DNA & Stem cell. The author has an hindex of 25, co-authored 51 publications receiving 3442 citations. Previous affiliations of Eunju Kang include Oregon Health & Science University & Gyeongsang National University.
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Journal ArticleDOI
Correction of a pathogenic gene mutation in human embryos
Hong Ma,Nuria Marti-Gutierrez,Sang-Wook Park,Jun Wu,Yeon-Mi Lee,Keiichiro Suzuki,Amy Koski,Dongmei Ji,Tomonari Hayama,Riffat Ahmed,Hayley Darby,Crystal Van Dyken,Ying Li,Eunju Kang,A. Reum Park,Daesik Kim,Sangtae Kim,Jianhui Gong,Ying Gu,Xun Xu,David Battaglia,Sacha A. Krieg,David M. Lee,Diana H. Wu,Don P. Wolf,Stephen B. Heitner,Juan Carlos Izpisua Belmonte,Paula Amato,Jin-Soo Kim,Sanjiv Kaul,Shoukhrat Mitalipov +30 more
TL;DR: The efficiency, accuracy and safety of the approach presented suggest that it has potential to be used for the correction of heritable mutations in human embryos by complementing preimplantation genetic diagnosis.
Journal ArticleDOI
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
Journal ArticleDOI
Towards germline gene therapy of inherited mitochondrial diseases
Masahito Tachibana,Paula Amato,Michelle Sparman,Joy Woodward,Dario Melguizo Sanchis,Hong Ma,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Eunju Kang,Hyo Sang Lee,Cathy Ramsey,Keith Masterson,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Shoukhrat Mitalipov,Shoukhrat Mitalipov +22 more
TL;DR: Although some ST oocytes displayed abnormal fertilization, remaining embryos were capable of developing to blastocysts and producing embryonic stem cells similar to controls.
Journal ArticleDOI
Abnormalities in human pluripotent cells due to reprogramming mechanisms
Hong Ma,Robert Morey,Ryan C. O’Neil,Ryan C. O’Neil,Yupeng He,Yupeng He,Brittany L. Daughtry,Matthew D. Schultz,Manoj Hariharan,Joseph R. Nery,Rosa Castanon,Karen Sabatini,Rathi D Thiagarajan,Masahito Tachibana,Eunju Kang,Rebecca Tippner-Hedges,Riffat Ahmed,Nuria Marti Gutierrez,Crystal Van Dyken,Alim Polat,Alim Polat,Atsushi Sugawara,Michelle Sparman,Sumita Gokhale,Paula Amato,Don P. Wolf,Joseph R. Ecker,Joseph R. Ecker,Louise C. Laurent,Shoukhrat Mitalipov,Shoukhrat Mitalipov +30 more
TL;DR: Human somatic cells can be faithfully reprogrammed to pluripotency by SCNT and are therefore ideal for cell replacement therapies.
Journal ArticleDOI
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Eunju Kang,Eunju Kang,Jun Wu,Nuria Marti Gutierrez,Amy Koski,Rebecca Tippner-Hedges,Karen Agaronyan,Aida Platero-Luengo,Paloma Martinez-Redondo,Hong Ma,Hong Ma,Yeon-Mi Lee,Tomonari Hayama,Crystal Van Dyken,Xinjian Wang,Shiyu Luo,Riffat Ahmed,Ying Li,Dongmei Ji,Dongmei Ji,Refik Kayali,Cengiz Cinnioglu,Susan B. Olson,Jeffrey T. Jensen,David Battaglia,David M. Lee,Diana Wu,Taosheng Huang,Don P. Wolf,Dmitry Temiakov,Juan Carlos Izpisua Belmonte,Paula Amato,Shoukhrat Mitalipov +32 more
TL;DR: A polymorphism within the conserved sequence box II region of the D-loop is identified as a plausible cause of preferential replication of specific mtDNA haplotypes, and a matching paradigm for selecting compatible donor mtDNA for MRT is proposed.