J
Jeffrey T. Jensen
Researcher at Oregon Health & Science University
Publications - 295
Citations - 7317
Jeffrey T. Jensen is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Population & Levonorgestrel. The author has an hindex of 41, co-authored 271 publications receiving 6501 citations. Previous affiliations of Jeffrey T. Jensen include Eastern Virginia Medical School & Oregon National Primate Research Center.
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Journal ArticleDOI
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
Journal ArticleDOI
Towards germline gene therapy of inherited mitochondrial diseases
Masahito Tachibana,Paula Amato,Michelle Sparman,Joy Woodward,Dario Melguizo Sanchis,Hong Ma,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Eunju Kang,Hyo Sang Lee,Cathy Ramsey,Keith Masterson,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Shoukhrat Mitalipov,Shoukhrat Mitalipov +22 more
TL;DR: Although some ST oocytes displayed abnormal fertilization, remaining embryos were capable of developing to blastocysts and producing embryonic stem cells similar to controls.
Journal ArticleDOI
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Eunju Kang,Eunju Kang,Jun Wu,Nuria Marti Gutierrez,Amy Koski,Rebecca Tippner-Hedges,Karen Agaronyan,Aida Platero-Luengo,Paloma Martinez-Redondo,Hong Ma,Hong Ma,Yeon-Mi Lee,Tomonari Hayama,Crystal Van Dyken,Xinjian Wang,Shiyu Luo,Riffat Ahmed,Ying Li,Dongmei Ji,Dongmei Ji,Refik Kayali,Cengiz Cinnioglu,Susan B. Olson,Jeffrey T. Jensen,David Battaglia,David M. Lee,Diana Wu,Taosheng Huang,Don P. Wolf,Dmitry Temiakov,Juan Carlos Izpisua Belmonte,Paula Amato,Shoukhrat Mitalipov +32 more
TL;DR: A polymorphism within the conserved sequence box II region of the D-loop is identified as a plausible cause of preferential replication of specific mtDNA haplotypes, and a matching paradigm for selecting compatible donor mtDNA for MRT is proposed.
Journal ArticleDOI
Continuous or extended cycle vs. cyclic use of combined hormonal contraceptives for contraception
TL;DR: The hypothesis was that continuous or extended-cycle CHCs have equivalent efficacy and safety but improved bleeding profiles, amenorrhea rates, adherence, continuation, participant satisfaction, and menstrual symptoms compared with standard cyclic CHCs.
Journal ArticleDOI
Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs
Eunju Kang,Eunju Kang,Xinjian Wang,Rebecca Tippner-Hedges,Rebecca Tippner-Hedges,Hong Ma,Hong Ma,Clifford D.L. Folmes,Nuria Marti Gutierrez,Nuria Marti Gutierrez,Yeon-Mi Lee,Yeon-Mi Lee,Crystal Van Dyken,Crystal Van Dyken,Riffat Ahmed,Riffat Ahmed,Ying Li,Ying Li,Amy Koski,Amy Koski,Tomonari Hayama,Tomonari Hayama,Shiyu Luo,Cary O. Harding,Paula Amato,Jeffrey T. Jensen,David Battaglia,David M. Lee,Diana Wu,Andre Terzic,Don P. Wolf,Don P. Wolf,Taosheng Huang,Shoukhrat Mitalipov +33 more
TL;DR: The frequency of mtDNA defects in iPSCs increased with age, and many mutations were non-synonymous or resided in RNA coding genes and thus can lead to respiratory defects, highlighting a need to monitor mtDNA mutations in i PSCs, especially those generated from older patients, and to examine the metabolic status of iPSC destined for clinical applications.