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Sumita Gokhale
Researcher at Roger Williams Medical Center
Publications - 13
Citations - 3645
Sumita Gokhale is an academic researcher from Roger Williams Medical Center. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 12, co-authored 13 publications receiving 3365 citations. Previous affiliations of Sumita Gokhale include Boston University & Massachusetts Institute of Technology.
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Journal ArticleDOI
YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells
Fernando D. Camargo,Sumita Gokhale,Jonathan B. Johnnidis,Dongdong Fu,George W. Bell,Rudolf Jaenisch,Thijn R. Brummelkamp +6 more
TL;DR: It is reported here that YAP1 increases organ size and causes aberrant tissue expansion in mice and that the Hippo signaling pathway regulates organ size in mammals and can act on stem cell compartments, indicating a potential link between stem/progenitor cells, organ size, and cancer.
Journal ArticleDOI
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
Journal ArticleDOI
Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal
Christopher J. Lengner,Fernando D. Camargo,Konrad Hochedlinger,G. Grant Welstead,Samir Zaidi,Sumita Gokhale,Hans R. Schöler,Alexey Tomilin,Rudolf Jaenisch +8 more
TL;DR: It is concluded that Oct4 is dispensable for both self-renewal and maintenance of somatic stem cells in the adult mammal.
Journal ArticleDOI
Towards germline gene therapy of inherited mitochondrial diseases
Masahito Tachibana,Paula Amato,Michelle Sparman,Joy Woodward,Dario Melguizo Sanchis,Hong Ma,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Eunju Kang,Hyo Sang Lee,Cathy Ramsey,Keith Masterson,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Shoukhrat Mitalipov,Shoukhrat Mitalipov +22 more
TL;DR: Although some ST oocytes displayed abnormal fertilization, remaining embryos were capable of developing to blastocysts and producing embryonic stem cells similar to controls.
Journal ArticleDOI
Abnormalities in human pluripotent cells due to reprogramming mechanisms
Hong Ma,Robert Morey,Ryan C. O’Neil,Ryan C. O’Neil,Yupeng He,Yupeng He,Brittany L. Daughtry,Matthew D. Schultz,Manoj Hariharan,Joseph R. Nery,Rosa Castanon,Karen Sabatini,Rathi D Thiagarajan,Masahito Tachibana,Eunju Kang,Rebecca Tippner-Hedges,Riffat Ahmed,Nuria Marti Gutierrez,Crystal Van Dyken,Alim Polat,Alim Polat,Atsushi Sugawara,Michelle Sparman,Sumita Gokhale,Paula Amato,Don P. Wolf,Joseph R. Ecker,Joseph R. Ecker,Louise C. Laurent,Shoukhrat Mitalipov,Shoukhrat Mitalipov +30 more
TL;DR: Human somatic cells can be faithfully reprogrammed to pluripotency by SCNT and are therefore ideal for cell replacement therapies.