M
Masahito Tachibana
Researcher at Tohoku University
Publications - 56
Citations - 2665
Masahito Tachibana is an academic researcher from Tohoku University. The author has contributed to research in topics: Embryonic stem cell & Somatic cell nuclear transfer. The author has an hindex of 18, co-authored 48 publications receiving 2436 citations. Previous affiliations of Masahito Tachibana include Oregon Health & Science University & Oregon National Primate Research Center.
Papers
More filters
Journal ArticleDOI
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
Journal ArticleDOI
Mitochondrial gene replacement in primate offspring and embryonic stem cells
Masahito Tachibana,Michelle Sparman,Hathaitip Sritanaudomchai,Hong Ma,Lisa Clepper,Joy Woodward,Ying Li,Cathy Ramsey,Olena Kolotushkina,Shoukhrat Mitalipov,Shoukhrat Mitalipov +10 more
TL;DR: It is demonstrated here that the mitochondrial genome can be efficiently replaced in mature non-human primate oocytes (Macaca mulatta) by spindle–chromosomal complex transfer from one egg to an enucleated, mitochondrial-replete egg.
Journal ArticleDOI
Towards germline gene therapy of inherited mitochondrial diseases
Masahito Tachibana,Paula Amato,Michelle Sparman,Joy Woodward,Dario Melguizo Sanchis,Hong Ma,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Eunju Kang,Hyo Sang Lee,Cathy Ramsey,Keith Masterson,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Shoukhrat Mitalipov,Shoukhrat Mitalipov +22 more
TL;DR: Although some ST oocytes displayed abnormal fertilization, remaining embryos were capable of developing to blastocysts and producing embryonic stem cells similar to controls.
Journal ArticleDOI
Abnormalities in human pluripotent cells due to reprogramming mechanisms
Hong Ma,Robert Morey,Ryan C. O’Neil,Ryan C. O’Neil,Yupeng He,Yupeng He,Brittany L. Daughtry,Matthew D. Schultz,Manoj Hariharan,Joseph R. Nery,Rosa Castanon,Karen Sabatini,Rathi D Thiagarajan,Masahito Tachibana,Eunju Kang,Rebecca Tippner-Hedges,Riffat Ahmed,Nuria Marti Gutierrez,Crystal Van Dyken,Alim Polat,Alim Polat,Atsushi Sugawara,Michelle Sparman,Sumita Gokhale,Paula Amato,Don P. Wolf,Joseph R. Ecker,Joseph R. Ecker,Louise C. Laurent,Shoukhrat Mitalipov,Shoukhrat Mitalipov +30 more
TL;DR: Human somatic cells can be faithfully reprogrammed to pluripotency by SCNT and are therefore ideal for cell replacement therapies.
Journal ArticleDOI
Generation of Chimeric Rhesus Monkeys
Masahito Tachibana,Michelle Sparman,Cathy Ramsey,Hong Ma,Hyo Sang Lee,Maria Cecilia T. Penedo,Shoukhrat Mitalipov,Shoukhrat Mitalipov +7 more
TL;DR: It is demonstrated that rhesus monkey embryonic stem cells and isolated ICMs fail to incorporate into host embryos and develop into chimeras, and it is suggested that a chimera assay using pluripotent cells may not be feasible.