M
Michelle Sparman
Researcher at Oregon National Primate Research Center
Publications - 17
Citations - 1531
Michelle Sparman is an academic researcher from Oregon National Primate Research Center. The author has contributed to research in topics: Embryonic stem cell & Somatic cell nuclear transfer. The author has an hindex of 11, co-authored 17 publications receiving 1437 citations. Previous affiliations of Michelle Sparman include Oregon Health & Science University.
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Journal ArticleDOI
Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana,Paula Amato,Michelle Sparman,Nuria Marti Gutierrez,Rebecca Tippner-Hedges,Hong Ma,Eunju Kang,Alimujiang Fulati,Hyo Sang Lee,Hathaitip Sritanaudomchai,Keith Masterson,Janine M. Larson,Deborah Eaton,K. Sadler-Fredd,David Battaglia,David M. Lee,Diana Wu,Jeffrey T. Jensen,Jeffrey T. Jensen,Phillip E. Patton,Sumita Gokhale,Richard L. Stouffer,Richard L. Stouffer,Don P. Wolf,Shoukhrat Mitalipov,Shoukhrat Mitalipov +25 more
TL;DR: Gene expression and differentiation profiles in human NT-ESCs were similar to embryo-derived ESCs, suggesting efficient reprogramming of somatic cells to a pluripotent state.
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Abnormalities in human pluripotent cells due to reprogramming mechanisms
Hong Ma,Robert Morey,Ryan C. O’Neil,Ryan C. O’Neil,Yupeng He,Yupeng He,Brittany L. Daughtry,Matthew D. Schultz,Manoj Hariharan,Joseph R. Nery,Rosa Castanon,Karen Sabatini,Rathi D Thiagarajan,Masahito Tachibana,Eunju Kang,Rebecca Tippner-Hedges,Riffat Ahmed,Nuria Marti Gutierrez,Crystal Van Dyken,Alim Polat,Alim Polat,Atsushi Sugawara,Michelle Sparman,Sumita Gokhale,Paula Amato,Don P. Wolf,Joseph R. Ecker,Joseph R. Ecker,Louise C. Laurent,Shoukhrat Mitalipov,Shoukhrat Mitalipov +30 more
TL;DR: Human somatic cells can be faithfully reprogrammed to pluripotency by SCNT and are therefore ideal for cell replacement therapies.
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Generation of Chimeric Rhesus Monkeys
Masahito Tachibana,Michelle Sparman,Cathy Ramsey,Hong Ma,Hyo Sang Lee,Maria Cecilia T. Penedo,Shoukhrat Mitalipov,Shoukhrat Mitalipov +7 more
TL;DR: It is demonstrated that rhesus monkey embryonic stem cells and isolated ICMs fail to incorporate into host embryos and develop into chimeras, and it is suggested that a chimera assay using pluripotent cells may not be feasible.
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Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck
Hyo Sang Lee,Hong Ma,Rita Cervera Juanes,Masahito Tachibana,Michelle Sparman,Joy Woodward,Cathy Ramsey,Jing Xu,Eun Ju Kang,Paula Amato,Georg Mair,Ralf Steinborn,Shoukhrat Mitalipov +12 more
TL;DR: Evidence is presented for a previously unknown mtDNA segregation and bottleneck during preimplantation embryo development, suggesting that return to the homoplasmic condition can occur during development of an individual organism from the zygote to birth, without a passage through the germline.
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Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases
TL;DR: Novel assisted reproductive techniques and their use to prevent transmission of mitochondrial disorders are summarized, focusing on their potential clinical application.