J
Joshua D. Stender
Researcher at University of California, San Diego
Publications - 22
Citations - 3312
Joshua D. Stender is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Transcription factor & Estrogen receptor. The author has an hindex of 17, co-authored 22 publications receiving 2871 citations. Previous affiliations of Joshua D. Stender include University of Illinois at Urbana–Champaign & Abbott Laboratories.
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Journal ArticleDOI
Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities
David Gosselin,Verena M. Link,Casey E. Romanoski,Gregory J. Fonseca,Dawn Z Eichenfield,Nathanael J. Spann,Joshua D. Stender,Hyun B. Chun,Hannah Garner,Frederic Geissmann,Christopher K. Glass +10 more
TL;DR: It is found that distinct tissue environments drive divergent programs of gene expression by differentially activating a common enhancer repertoire and by inducing the expression of divergent secondary transcription factors that collaborate with PU.1 to establish tissue-specific enhancers.
Journal ArticleDOI
Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription
Minna U. Kaikkonen,Nathanael J. Spann,Sven Heinz,Casey E. Romanoski,Karmel A. Allison,Joshua D. Stender,Hyun B. Chun,David F. Tough,Rab K. Prinjha,Christopher Benner,Christopher K. Glass +10 more
TL;DR: An essential role of enhancer transcription in H3K4me1/2 deposition at de novo enhancers that is independent of potential functions of the resulting eRNA transcripts is suggested.
Journal Article
Gene Expression Profiling of Multiple Histone Deacetylase (HDAC) Inhibitors: Defining a Common Gene Set Produced by HDAC Inhibition in T24 and MDA Carcinoma Cell Lines
Keith B. Glaser,Michael J. Staver,Jeffrey F. Waring,Joshua D. Stender,Roger G. Ulrich,Steven K. Davidsen +5 more
TL;DR: Researchers studied the gene expression profiles of T24 bladder and MDA breast carcinoma cells treated with three HDAC inhibitors to understand the genomic effects of HDAC inhibition on gene transcription, which may be responsible for antitumor effects.
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Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation
Joshua D. Stender,Kyuri Kim,Tze Howe Charn,Barry S. Komm,Ken C. N. Chang,W. Lee Kraus,Christopher Benner,Christopher K. Glass,Benita S. Katzenellenbogen +8 more
TL;DR: The findings delineate the contributions of direct receptor ERE binding versus binding through response elements for other transcription factors in chromatin localization and ER-dependent gene regulation, paradigms likely to underlie the gene regulatory actions of other nuclear receptors as well.
Journal ArticleDOI
Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20
Joshua D. Stender,Gabriel Pascual,Wen Liu,Minna U. Kaikkonen,Minna U. Kaikkonen,Kevin Do,Nathanael J. Spann,Michael Boutros,Norbert Perrimon,Norbert Perrimon,Michael G. Rosenfeld,Michael G. Rosenfeld,Christopher K. Glass +12 more
TL;DR: Evidence for the role of trimethylated histone H4 lysine 20 (H4K20me3) as a repression checkpoint that restricts expression of toll-like receptor 4 (TLR4) target genes in macrophages is provided.