R
Rolando Cimaz
Researcher at University of Milan
Publications - 512
Citations - 19359
Rolando Cimaz is an academic researcher from University of Milan. The author has contributed to research in topics: Arthritis & Medicine. The author has an hindex of 63, co-authored 477 publications receiving 16483 citations. Previous affiliations of Rolando Cimaz include University of Ljubljana & University of Aberdeen.
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Journal ArticleDOI
Drug Retention Rate and Predictive Factors of Drug Survival for Interleukin-1 Inhibitors in Systemic Juvenile Idiopathic Arthritis.
Jurgen Sota,Antonella Insalaco,Rolando Cimaz,Maria Alessio,Marco Cattalini,Romina Gallizzi,Maria Cristina Maggio,Giuseppe Lopalco,Francesco La Torre,Claudia Fabiani,M Pardeo,Alma Nunzia Olivieri,Paolo Sfriso,Carlo Salvarani,Carla Gaggiano,Salvatore Grosso,Claudia Bracaglia,Fabrizio De Benedetti,Donato Rigante,Luca Cantarini +19 more
TL;DR: In this article, the authors investigated the drug retention rate of interleukin (IL)-1 inhibitors on systemic JIA (sJIA) patients and evaluated predictive factors of drug survival based on data from a real-world setting concerning sJIA.
Journal ArticleDOI
Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis
Nicolino Ruperto,Hermine I. Brunner,Pierre Quartier,Tamás Constantin,Nico M Wulffraat,Gerd Horneff,Riva Brik,Liza J McCann,Ozgur Kasapcopur,Lidia Rutkowska-Sak,Rayfel Schneider,Yackov Berkun,Inmaculada Calvo,Muferet Erguven,Laurence Goffin,Michael Hofer,Tilmann Kallinich,Sheila Knupp Feitosa de Oliveira,Yosef Uziel,Stefania Viola,Kiran Nistala,Carine Wouters,Rolando Cimaz,Manuel A. Ferrandiz,Berit Flatø,M.L. Gamir,Isabelle Koné-Paut,Alexei A. Grom,Bo Magnusson,Seza Ozen,Flavio Sztajnbok,Karine Lheritier,Ken Abrams,Dennis Y. Kim,Alberto Martini,Alberto Martini,Daniel J. Lovell +36 more
TL;DR: These two phase 3 studies show the efficacy and safety of canakinumab in systemic JIA with active systemic features, and among the 100 patients who underwent randomization in the withdrawal phase, the risk of flare was lower among patients who continued to receive canakinUMab than among those who were switched to placebo.
Journal ArticleDOI
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
Pierre Quartier,Florence Allantaz,Rolando Cimaz,Pascal Pillet,Claude Messiaen,Christophe Bardin,Xavier Bossuyt,Anne Boutten,Jacques Bienvenu,Agnès Duquesne,O. Richer,Damien Chaussabel,Agnes Mogenet,Jacques Banchereau,Jean-Marc Tréluyer,Paul Landais,Virginia Pascual +16 more
TL;DR: Anakinra treatment is effective in SJIA, at least in the short term, and is associated with normalisation of blood gene expression profiles in clinical responders and induces a de novo IFN signature.
Journal ArticleDOI
Anti-inflammatory and immunosuppressive drugs and reproduction.
Monika Østensen,Munther A. Khamashta,Michael D. Lockshin,Ann L. Parke,Antonio Brucato,Howard Carp,Andrea Doria,Raj Rai,Pier Luigi Meroni,Irene Cetin,Ronald H. W. M. Derksen,Ware Branch,Mario Motta,Caroline Gordon,Guillermo Ruiz-Irastorza,Arsenio Spinillo,Deborah I. Friedman,Rolando Cimaz,Andrew Czeizel,J.C. Piette,Ricard Cervera,Roger A. Levy,Maurizio Clementi,Sara De Carolis,Michelle Petri,Yehuda Shoenfeld,D Faden,Guido Valesini,Angela Tincani +28 more
TL;DR: Benefits of anti-inflammatory, immunosuppressive and biological drugs during pregnancy and lactation, effects of these drugs on male and female fertility and possible long-term effects on infants exposed to drugs antenatally are discussed.
Journal ArticleDOI
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
Gillian I. Rice,Yoandris del Toro Duany,Yoandris del Toro Duany,Emma M. Jenkinson,Gabriella M A Forte,Beverley Anderson,Giada Ariaudo,Brigitte Bader-Meunier,Eileen Baildam,Roberta Battini,Michael W. Beresford,Manuela Casarano,Mondher Chouchane,Rolando Cimaz,Abigail Collins,Nuno Cordeiro,Russell C. Dale,Joyce Davidson,Liesbeth De Waele,Isabelle Desguerre,Laurence Faivre,Elisa Fazzi,Bertrand Isidor,Lieven Lagae,Andrew Latchman,Pierre Lebon,Chumei Li,John H. Livingston,Charles Marques Lourenço,Maria Margherita Mancardi,Alice Masurel-Paulet,Iain B. McInnes,Manoj P. Menezes,Cyril Mignot,James O'Sullivan,Simona Orcesi,Paolo Picco,Enrica Riva,Robert Robinson,Diana Rodriguez,Diana Rodriguez,Elisabetta Salvatici,Christiaan Scott,Marta Szybowska,John Tolmie,Adeline Vanderver,Catherine Vanhulle,José Pedro Vieira,Kate Webb,Robyn Whitney,Simon G. Williams,Lynne A. Wolfe,Sameer M. Zuberi,Sameer M. Zuberi,Sun Hur,Sun Hur,Yanick J. Crow +56 more
TL;DR: It is demonstrated that aberrant sensing of nucleic acids can cause immune upregulation and heterozygous mutations in the cytosolic double-stranded RNA receptor gene IFIH1 (also called MDA5) cause a spectrum of neuroimmunological features consistently associated with an enhanced interferon state.