J
Jonathan Stefanowski
Researcher at Humboldt University of Berlin
Publications - 10
Citations - 1286
Jonathan Stefanowski is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Bone regeneration & Bone healing. The author has an hindex of 6, co-authored 10 publications receiving 988 citations. Previous affiliations of Jonathan Stefanowski include Charité & Leibniz Association.
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Journal ArticleDOI
Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease.
Noah W. Palm,Marcel R. de Zoete,Marcel R. de Zoete,Thomas W. Cullen,Natasha A. Barry,Jonathan Stefanowski,Liming Hao,Patrick H. Degnan,Jianzhong Hu,Inga Peter,Wei Zhang,Elizabeth Ruggiero,Judy H. Cho,Andrew L. Goodman,Richard A. Flavell,Richard A. Flavell +15 more
TL;DR: In this paper, the authors used flow-cytometry-based bacterial cell sorting and 16S sequencing to characterize taxa-specific coating of the intestinal microbiota with immunoglobulin A (IgA-SEQ) and show that high IgA coating uniquely identifies colitogenic intestinal bacteria in a mouse model of microbiota-driven colitis.
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Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.
René Riedel,Richard K. Addo,Marta Ferreira-Gomes,Gitta Anne Heinz,Frederik Heinrich,Jannis Kummer,Victor Greiff,Victor Greiff,Daniel Schulz,Cora Klaeden,Rebecca Cornelis,Ulrike Menzel,Stefan Kröger,Stefan Kröger,Ulrik Stervbo,Ralf Köhler,Claudia Haftmann,Silvia Kühnel,Katrin Lehmann,Patrick Maschmeyer,Mairi McGrath,Sandra Naundorf,Stefanie Hahne,Özen Sercan-Alp,Francesco Siracusa,Jonathan Stefanowski,Melanie Weber,Kerstin Westendorf,Jakob Zimmermann,Anja E. Hauser,Sai T. Reddy,Pawel Durek,Hyun-Dong Chang,Mir-Farzin Mashreghi,Andreas Radbruch +34 more
TL;DR: It is shown, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched memory B cells to potentially optimize for rapid recall responses.
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DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
Laura Herrtwich,Indrajit Nanda,Konstantinos Evangelou,Teodora Nikolova,Veronika Horn,Sagar,Daniel Erny,Jonathan Stefanowski,Leif Rogell,Leif Rogell,Claudius Klein,Kourosh Gharun,Marie Follo,Maximilian Seidl,Bernhard Kremer,Nikolas Münke,Julia Senges,Manfred Fliegauf,Tom Aschman,Dietmar Pfeifer,Sandrine Sarrazin,Michael H. Sieweke,Dirk Wagner,Christine Dierks,Thomas Haaf,Thomas Ness,Mario M. Zaiss,Reinhard E. Voll,Sachin D. Deshmukh,Marco Prinz,Torsten Goldmann,Christoph Hölscher,Anja E. Hauser,Andrés J. López-Contreras,Dominic Grün,Vassilis G. Gorgoulis,Andreas Diefenbach,Philipp Henneke,Antigoni Triantafyllopoulou +38 more
TL;DR: It is proposed that, in the presence of persistent inflammatory stimuli, pathways previously linked to oncogene-initiated carcinogenesis instruct a long-lived granuloma-resident macrophage differentiation program that regulates granulomatous tissue remodeling.
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Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature
David Reismann,Jonathan Stefanowski,Jonathan Stefanowski,Robert Günther,Asylkhan Rakhymzhan,Romano Matthys,Reto Nützi,Sandra Zehentmeier,Sandra Zehentmeier,Sandra Zehentmeier,Katharina Schmidt-Bleek,Georg Petkau,Hyun-Dong Chang,Sandra Naundorf,York Winter,Fritz Melchers,Georg N. Duda,Anja E. Hauser,Anja E. Hauser,Raluca Niesner +19 more
TL;DR: A microendoscopic multi-photon imaging approach called LIMB (longitudinal intravital imaging of the bone marrow) is developed to analyze cellular dynamics within the deep marrow and reveals extensive vascular plasticity within the marrow during bone healing and steady-state homeostasis.
Journal ArticleDOI
Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels.
Jonathan Stefanowski,Annemarie Lang,Annemarie Lang,Ariana Rauch,Linus Aulich,Markus Köhler,Alexander Ferdinand Fiedler,Frank Buttgereit,Frank Buttgereit,Katharina Schmidt-Bleek,Georg N. Duda,Timo Gaber,Timo Gaber,Raluca A. Niesner,Raluca A. Niesner,Anja E. Hauser,Anja E. Hauser +16 more
TL;DR: This work phenotype the phases of vascular regeneration—the expansion phase (d1–d7 after injury) and the remodeling phase of the endothelial network, until tissue integrity is restored (d14–d21 after injury).