J
Joachim R. Grün
Researcher at Leibniz Institute for Neurobiology
Publications - 34
Citations - 1965
Joachim R. Grün is an academic researcher from Leibniz Institute for Neurobiology. The author has contributed to research in topics: Tumor necrosis factor alpha & Immune system. The author has an hindex of 18, co-authored 32 publications receiving 1715 citations.
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Journal ArticleDOI
Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow.
Koji Tokoyoda,Sandra Zehentmeier,Ahmed N. Hegazy,Inka Albrecht,Joachim R. Grün,Max Löhning,Andreas Radbruch +6 more
TL;DR: In the memory phase of immunity, memory helper T cells are maintained in BM as resting but highly reactive cells in survival niches defined by IL-7-expressing stroma cells.
Journal ArticleDOI
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes
Anna-Barbara Stittrich,Claudia Haftmann,Evridiki Sgouroudis,Anja A. Kühl,Ahmed N. Hegazy,Isabel Panse,René Riedel,Michael Flossdorf,Jun Dong,Franziska Fuhrmann,Gitta Anne Heinz,Zhuo Fang,Na Li,Ute Bissels,Farahnaz Hatam,Angelina Jahn,Ben Hammoud,Mareen Matz,Felix Michael Schulze,Ria Baumgrass,Andreas Bosio,Hans-Joachim Mollenkopf,Joachim R. Grün,Andreas Thiel,Wei Chen,Thomas Höfer,Christoph Loddenkemper,Max Löhning,Hyun-Dong Chang,Nikolaus Rajewsky,Andreas Radbruch,Mir-Farzin Mashreghi +31 more
TL;DR: A central role for miR-182 is demonstrated in the physiological regulation of IL-2-driven helper T cell–mediated immune responses and new therapeutic possibilities are opened.
Journal ArticleDOI
Sialic acid–binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus
Robert Biesen,Robert Biesen,Cemal Demir,Fidan Barkhudarova,Fidan Barkhudarova,Joachim R. Grün,Marta Steinbrich-Zöllner,Marina Backhaus,Marina Backhaus,Thomas Häupl,Thomas Häupl,Martin Rudwaleit,Martin Rudwaleit,Gabriela Riemekasten,Gabriela Riemekasten,Andreas Radbruch,Andreas Radbruch,Falk Hiepe,Falk Hiepe,Gerd-Rüdiger Burmester,Gerd-Rüdiger Burmester,Andreas Grützkau +21 more
TL;DR: The findings indicate that Siglec-1 expression in resident blood monocytes is a potential biomarker for monitoring disease activity, displaying type I IFN responses, and estimating levels of anti-dsDNA antibodies.
Journal ArticleDOI
A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow.
Henrik E. Mei,Henrik E. Mei,Ina Wirries,Ina Wirries,Daniela Frölich,Daniela Frölich,Mikael Brisslert,Claudia Giesecke,Claudia Giesecke,Joachim R. Grün,Tobias Alexander,Tobias Alexander,Stefanie Schmidt,Stefanie Schmidt,Katarzyna Luda,Katarzyna Luda,Anja A. Kühl,Robby Engelmann,Michael Dürr,Tobias Scheel,Maria Bokarewa,Carsten Perka,Andreas Radbruch,Thomas Dörner,Thomas Dörner +24 more
TL;DR: A multilayer model of PC memory is proposed in which CD19(+) andCD19(-) PC represent dynamic and static components, respectively, permitting both adaptation and stability of humoral immune protection.
Journal ArticleDOI
Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory
Anna Okhrimenko,Joachim R. Grün,Kerstin Westendorf,Zhuo Fang,Simon Reinke,Philipp von Roth,Georgi I. Wassilew,Anja A. Kühl,Robert Kudernatsch,Sonya Demski,Carmen Scheibenbogen,Koji Tokoyoda,Mairi McGrath,Martin Raftery,Günther Schönrich,Alessandro Serra,Hyun-Dong Chang,Andreas Radbruch,Jun Dong +18 more
TL;DR: It is shown that human bone marrow professional memory T cells are not activated but are resting in terms of proliferation, transcription, and mobility, and they are in the G0 phase of the cell cycle, and their transcriptome is that of resting T cells.