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In Hak Choi
Researcher at Inje University
Publications - 7
Citations - 1746
In Hak Choi is an academic researcher from Inje University. The author has contributed to research in topics: Antigen-presenting cell & ZAP70. The author has an hindex of 7, co-authored 7 publications receiving 1574 citations. Previous affiliations of In Hak Choi include Mayo Clinic.
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Journal ArticleDOI
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Gabriel Sica,In Hak Choi,In Hak Choi,Gefeng Zhu,Koji Tamada,Shengdian Wang,Hideto Tamura,Andrei I. Chapoval,Dallas B. Flies,Jürgen Bajorath,Jürgen Bajorath,Lieping Chen +11 more
TL;DR: A B7 family molecule, B7-H4, is identified by protein sequence analysis and comparative molecular modeling and may participate in negative regulation of cell-mediated immunity in peripheral tissues.
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Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-γ-induced upregulation of B7-H1 (CD274)
Seung Jin Lee,Byeong Churl Jang,Soo Woong Lee,Young Il Yang,Seong Il Suh,Yeong Min Park,Sangtaek Oh,Jae-Gook Shin,Sheng Yao,Lieping Chen,In Hak Choi +10 more
TL;DR: A critical role of IRF‐1 is found in the regulation of constitutive and IFN‐γ‐induced expression of B7‐H1 in cancer cells, and AG490, a Janus activated kinase/signal transducer and activator of transcription inhibitor, greatly abolished the responsiveness of A549 cells to IFN-γ by reducing the IRF•1 transcription.
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Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family
In Hak Choi,Gefeng Zhu,Gabriel Sica,Scott E. Strome,John C. Cheville,Julie S. Lau,Yuwen Zhu,Dallas B. Flies,Koji Tamada,Lieping Chen +9 more
TL;DR: It is reported that the genomic DNA of human B7-H4 is mapped on chromosome 1 comprised of six exons and five introns spanning 66 kb, of which exon 6 is used for alternative splicing to generate two different transcripts.
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PD-1 on Dendritic Cells Impedes Innate Immunity Against Bacterial Infection
Sheng Yao,Shengdian Wang,Yuwen Zhu,Liqun Luo,Gefeng Zhu,Sarah J. Flies,Haiying Xu,William Ruff,Megan Broadwater,In Hak Choi,Koji Tamada,Lieping Chen +11 more
TL;DR: Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes and reveals a novel role ofPD-1 in the negative regulation of DC function during innate immune response.
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Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.
Sudarshan Anand,Pu Wang,Kiyoshi Yoshimura,In Hak Choi,Anja Hilliard,Youhai H. Chen,Chyung Ru Wang,Richard D. Schulick,Andrew S. Flies,Dallas B. Flies,Gefeng Zhu,Yanhui Xu,Drew M. Pardoll,Lieping Chen,Koji Tamada +14 more
TL;DR: It is reported here that LIGHT is upregulated and functions as a proinflammatory cytokine in 2 independent experimental hepatitis models, induced by concanavalin A and Listeria monocytogenes.