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Anika Grüneboom
Researcher at University of Erlangen-Nuremberg
Publications - 36
Citations - 1263
Anika Grüneboom is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 10, co-authored 23 publications receiving 571 citations. Previous affiliations of Anika Grüneboom include University of Duisburg-Essen.
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Journal ArticleDOI
Locally renewing resident synovial macrophages provide a protective barrier for the joint
Stephan Culemann,Anika Grüneboom,José Ángel Nicolás-Ávila,Daniela Weidner,Katrin Franziska Lämmle,Tobias Rothe,Juan A. Quintana,Philipp Kirchner,Branislav Krljanac,Martin Eberhardt,Fulvia Ferrazzi,Elke Kretzschmar,Martin Schicht,Kim Fischer,Kolja Gelse,Maria Faas,R Pfeifle,Jochen A. Ackermann,Milena L Pachowsky,Nina Renner,David Simon,Reiner F. Haseloff,Arif B. Ekici,Tobias Bäuerle,Ingolf E. Blasig,Julio Vera,David Voehringer,Arnd Kleyer,Friedrich Paulsen,Georg Schett,Andrés Hidalgo,Gerhard Krönke +31 more
TL;DR: Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.
Journal ArticleDOI
A network of trans-cortical capillaries as mainstay for blood circulation in long bones
Anika Grüneboom,Ibrahim Hawwari,Daniela Weidner,Stephan Culemann,Sylvia Müller,Sophie Henneberg,Alexandra Brenzel,Simon F. Merz,Lea Bornemann,Kristina Zec,Manuela Wuelling,Lasse Kling,Mike Hasenberg,Sylvia Voortmann,Stefanie C. Lang,Wolfgang Baum,Alexandra Ohs,Oliver Kraff,Harald H. Quick,Harald H. Quick,Marcus Jäger,Stefan Landgraeber,Marcel Dudda,Renzo Danuser,Jens V. Stein,Manfred Rohde,Kolja Gelse,Annette I. Garbe,Alexandra Adamczyk,Astrid M. Westendorf,Daniel Hoffmann,Silke Christiansen,Silke Christiansen,Daniel R. Engel,Andrea Vortkamp,Gerhard Krönke,Martin Herrmann,Thomas Kamradt,Georg Schett,Anja Hasenberg,Matthias Gunzer +40 more
TL;DR: Tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature are identified, and it is shown that the majority of blood in long bones passes through TCVs.
Journal ArticleDOI
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Christina Heichler,Kristina Scheibe,Anabel Schmied,Carol Geppert,Benjamin Schmid,Stefan Wirtz,Oana-Maria Thoma,Viktoria Kramer,Maximilian J. Waldner,Christian Büttner,Henner F. Farin,Marina Pesic,Ferdinand Knieling,Susanne Merkel,Anika Grüneboom,Matthias Gunzer,Robert Grützmann,Stefan Rose-John,Sergei B. Koralov,George Kollias,Michael Vieth,Arndt Hartmann,Florian R. Greten,Markus F. Neurath,Clemens Neufert +24 more
TL;DR: A critical role of STAT3 activation in fibroblasts in driving colorectal tumourigenesis in vivo is found and a negative correlation of increased stromal pSTAT3 expression with the survival of colon cancer patients is revealed.
Journal ArticleDOI
Neutrophil Extracellular Traps Initiate Gallstone Formation.
Luis E. Muñoz,Sebastian Boeltz,Rostyslav Bilyy,Rostyslav Bilyy,Christine Schauer,Aparna Mahajan,Navena Widulin,Anika Grüneboom,Irmgard Herrmann,Edgyda Boada,Manfred Rauh,Veit Krenn,Mona H C Biermann,Malgorzata J. Podolska,Jonas Hahn,Jasmin Knopf,Christian Maueröder,Solomiya Paryzhak,Tetiana Dumych,Yi Zhao,Markus F. Neurath,Markus H. Hoffmann,Tobias A. Fuchs,Moritz Leppkes,Georg Schett,Martin Herrmann +25 more
TL;DR: It is shown that after the physicochemical process of crystal formation, NETs foster their assembly into larger aggregates and finally gallstones, and these insights provide a feasible therapeutic concept to prevent cholelithiasis in patients at risk.
Journal ArticleDOI
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Jasna Friščić,Martin Böttcher,Christiane Reinwald,Heiko Bruns,Benjamin Wirth,Samantha-Josefine Popp,Kellie Irene Walker,Jochen A. Ackermann,Xi Chen,Jason D. Turner,Honglin Zhu,Honglin Zhu,Lisa Seyler,Maximilien Euler,Philipp Kirchner,René Krüger,Arif B. Ekici,Triin Major,Oliver Aust,Daniela Weidner,Anita Fischer,Fabian T. Andes,Zeljka Stanojevic,Vladimir Trajkovic,Martin Herrmann,Adelheid Korb-Pap,Isabel Wank,Andreas Hess,Johnathan Winter,Viktor Wixler,Jörg H W Distler,Günter Steiner,Hans P. Kiener,Benjamin Frey,Lasse Kling,Karim Raza,Silke Frey,Arnd Kleyer,Tobias Bäuerle,Timothy R. Hughes,Anika Grüneboom,Ulrike Steffen,Gerhard Krönke,Adam P. Croft,Andrew Filer,Jörg Köhl,Jörg Köhl,Katja Klein,Christopher D. Buckley,Christopher D. Buckley,Georg Schett,Dimitrios Mougiakakos,Markus H. Hoffmann +52 more
TL;DR: In this paper, the molecular and cellular mechanisms of inflammatory tissue priming are defined and the checkpoints between remission and persistence remain unknown. But, they suggest possibilities for therapeutic intervention abrogating tissue pre-priming without immunosuppression.