J
José Ángel Nicolás-Ávila
Researcher at Centro Nacional de Investigaciones Cardiovasculares
Publications - 15
Citations - 1709
José Ángel Nicolás-Ávila is an academic researcher from Centro Nacional de Investigaciones Cardiovasculares. The author has contributed to research in topics: Inflammation & Macrophage. The author has an hindex of 9, co-authored 13 publications receiving 914 citations.
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Journal ArticleDOI
Locally renewing resident synovial macrophages provide a protective barrier for the joint
Stephan Culemann,Anika Grüneboom,José Ángel Nicolás-Ávila,Daniela Weidner,Katrin Franziska Lämmle,Tobias Rothe,Juan A. Quintana,Philipp Kirchner,Branislav Krljanac,Martin Eberhardt,Fulvia Ferrazzi,Elke Kretzschmar,Martin Schicht,Kim Fischer,Kolja Gelse,Maria Faas,R Pfeifle,Jochen A. Ackermann,Milena L Pachowsky,Nina Renner,David Simon,Reiner F. Haseloff,Arif B. Ekici,Tobias Bäuerle,Ingolf E. Blasig,Julio Vera,David Voehringer,Arnd Kleyer,Friedrich Paulsen,Georg Schett,Andrés Hidalgo,Gerhard Krönke +31 more
TL;DR: Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.
Journal ArticleDOI
Neutrophils in Homeostasis, Immunity, and Cancer
TL;DR: This review focuses on emerging functions of neutrophils in homeostasis, immunity, and disease and identifies transcriptional and phenotypic diversity that endows them with regulatory properties that extend beyond their lifetime in the circulation.
Journal ArticleDOI
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
José Ángel Nicolás-Ávila,Ana Victoria Lechuga-Vieco,Lorena Esteban-Martínez,María Sánchez-Díaz,Elena Díaz-García,Demetrio J. Santiago,Andrea Rubio-Ponce,Jackson LiangYao Li,Jackson LiangYao Li,Akhila Balachander,Juan A. Quintana,Raquel Martínez-de-Mena,Beatriz Castejón-Vega,Andrés Pun-García,Paqui G. Través,Elena Bonzón-Kulichenko,Fernando García-Marqués,Lorena Cussó,Noelia A-Gonzalez,Noelia A-Gonzalez,Andrés González-Guerra,Marta Roche-Molina,Sandra Martín-Salamanca,Georgiana Crainiciuc,Gabriela Guzmán,Gabriela Guzmán,Jagoba Larrazabal,Elías Herrero-Galán,Jorge Alegre-Cebollada,Greg Lemke,Carla V. Rothlin,Luis Jesús Jiménez-Borreguero,Guillermo Reyes,Antonio Castrillo,Antonio Castrillo,Manuel Desco,Manuel Desco,Pura Muñoz-Cánoves,Pura Muñoz-Cánoves,Borja Ibanez,Miguel Torres,Lai Guan Ng,Silvia G. Priori,Silvia G. Priori,Héctor Bueno,Jesús Vázquez,Mario D. Cordero,Mario D. Cordero,Juan A. Bernal,José Antonio Enríquez,Andrés Hidalgo +50 more
TL;DR: An immune-parenchymal pair is identified in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function.
Journal ArticleDOI
Phagocytosis imprints heterogeneity in tissue-resident macrophages.
Noelia A-Gonzalez,Juan A. Quintana,Susana García-Silva,Marina S. Mazariegos,Arturo González de la Aleja,José Ángel Nicolás-Ávila,Wencke Walter,José M. Adrover,Georgiana Crainiciuc,Vijay K. Kuchroo,Carla V. Rothlin,Héctor Peinado,Antonio Castrillo,Mercedes Ricote,Andrés Hidalgo,Andrés Hidalgo +15 more
TL;DR: Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile that acts together with tissue-derived factors to preserve homeostasis.
Journal ArticleDOI
Co-option of Neutrophil Fates by Tissue Environments.
Iván Ballesteros,Andrea Rubio-Ponce,Marco Genua,Eleonora Lusito,Immanuel Kwok,Gabriel Fernández-Calvo,Tariq E. Khoyratty,Erinke van Grinsven,Sara González-Hernández,José Ángel Nicolás-Ávila,Tommaso Vicanolo,Antonio Maccataio,Alberto Benguria,Jackson LiangYao Li,Jackson LiangYao Li,José M. Adrover,Alejandra Aroca-Crevillen,Juan A. Quintana,Sandra Martín-Salamanca,Francisco Mayo,Stefanie Ascher,Giulia Barbiera,Oliver Soehnlein,Matthias Gunzer,Florent Ginhoux,Fátima Sánchez-Cabo,Estanislao Nistal-Villán,Christian Schulz,Ana Dopazo,Christoph Reinhardt,Irina A. Udalova,Lai Guan Ng,Renato Ostuni,Andrés Hidalgo,Andrés Hidalgo +34 more
TL;DR: This work uses a new model to track neutrophil fates and reveals that tissues co-opt neutrophils en route for elimination to induce programs that support their physiological demands, including vascular repair and hematoietic homeostasis.