Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Sonja Krugmann,Ingrid Jordens,Kris Gevaert,Mariëtte H.E. Driessens,Joël Vandekerckhove,Alan Hall +5 more
TLDR
It is concluded that the interaction of Cdc42 with the partial CRIB motif of IRSp53 relieves an intramolecular, autoinhibitory interaction with the N terminus, allowing the recruitment of Mena to theIRSp53 SH3 domain.About:
This article is published in Current Biology.The article was published on 2001-10-30 and is currently open access. It has received 391 citations till now. The article focuses on the topics: Filopodia & Ena/Vasp homology proteins.read more
Citations
More filters
Journal ArticleDOI
Local force and geometry sensing regulate cell functions.
Viola Vogel,Michael P. Sheetz +1 more
TL;DR: Tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms of eukaryotic cells.
Journal ArticleDOI
Rho and Rac Take Center Stage
TL;DR: This work will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins.
Journal ArticleDOI
Filopodia: molecular architecture and cellular functions
TL;DR: The increased understanding of the functions of various actin-associated proteins during the initiation and elongation of filopodia has provided new information on the mechanisms of filipodia formation in distinct cell types.
Journal ArticleDOI
The role of the Rho GTPases in neuronal development
TL;DR: The role of the Rho GTPases and their associated signaling molecules throughout neuronal development is focused on and how perturbations in RHo GTPase signaling may lead to cognitive disorders are discussed.
Journal ArticleDOI
The WASP-WAVE protein network: connecting the membrane to the cytoskeleton.
TL;DR: Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins are scaffolds that link upstream signals to the activation of the ARP2/3 complex, leading to a burst of actin polymerization.
References
More filters
Journal ArticleDOI
Rho GTPases and the Actin Cytoskeleton
TL;DR: Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Anne J. Ridley,Alan Hall +1 more
TL;DR: Rho, a ras-related GTP-binding protein, rapidly stimulated stress fiber and focal adhesion formation when microinjected into serum-starved Swiss 3T3 cells, implying that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
Journal ArticleDOI
Rho GTPases and their effector proteins.
Anne L. Bishop,Alan Hall +1 more
TL;DR: The main focus of this review will be Rho, Rac and Cdc42, the three best characterized mammalian Rho GTPases, though the genetic analysis of RhoGTPases in lower eukaryotes is making increasingly important contributions to this field.
Related Papers (5)
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more