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Inha Heo
Researcher at Royal Netherlands Academy of Arts and Sciences
Publications - 6
Citations - 1006
Inha Heo is an academic researcher from Royal Netherlands Academy of Arts and Sciences. The author has contributed to research in topics: Organoid & LGR5. The author has an hindex of 5, co-authored 6 publications receiving 627 citations. Previous affiliations of Inha Heo include Janssen Pharmaceutica.
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Journal ArticleDOI
Disease Modeling in Stem Cell-Derived 3D Organoid Systems
TL;DR: Recent advances in the application of organoids in studying cancer and hereditary diseases, as well as in the examination of host cell-microorganism interactions are discussed.
Journal ArticleDOI
Modelling Cryptosporidium infection in human small intestinal and lung organoids.
Inha Heo,Devanjali Dutta,Deborah A. Schaefer,Nino Iakobachvili,Benedetta Artegiani,Norman Sachs,Kim E Boonekamp,Gregory D. Bowden,Antoni P. A. Hendrickx,Robert J L Willems,Peter J. Peters,Michael W. Riggs,Roberta M. O'Connor,Hans Clevers +13 more
TL;DR: It is shown that Cryptosporidium can infect epithelial organoids derived from human small intestine and lung, where it replicates and completes its complex lifecycle.
Journal ArticleDOI
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids
Benedetta Artegiani,Lisa van Voorthuijsen,Rik G.H. Lindeboom,Danielle Seinstra,Inha Heo,Pablo Tapia,Carmen López-Iglesias,Daniel Postrach,Talya L. Dayton,Rurika Oka,Huili Hu,Ruben van Boxtel,Johan H. van Es,Johan Offerhaus,Peter J. Peters,Jacco van Rheenen,Michiel Vermeulen,Hans Clevers +17 more
TL;DR: Organoid technology combined with CRISPR/Cas9 provides an experimental platform for mechanistic studies of cancer gene function in a human context and finds that BAP1 controls the expression of junctional and cytoskeleton components by regulating chromatin accessibility.
Journal ArticleDOI
Intestinal organoid cocultures with microbes.
Jens Puschhof,Cayetano Pleguezuelos-Manzano,Adriana Martinez-Silgado,Ninouk Akkerman,Aurelia Saftien,Charelle Boot,Amy de Waal,Joep Beumer,Devanjali Dutta,Devanjali Dutta,Inha Heo,Inha Heo,Hans Clevers +12 more
TL;DR: In this paper, the authors provide detailed protocols for characterizing the coculture with regard to bacterial and organoid cell viability and growth kinetics, as well as considerations for assessing the impact of bacteria on gene expression and mutations through RNA and DNA sequencing.
Journal ArticleDOI
Identification of novel human Wnt target genes using adult endodermal tissue-derived organoids.
Kim E Boonekamp,Inha Heo,Benedetta Artegiani,Priyanca Asra,Gijs van Son,Joep de Ligt,Hans Clevers +6 more
TL;DR: In this paper, the authors identify the transcriptional targets of Wnt signaling in five human tissues using organoid technology and provide evidence for a conserved role for these Wnt targets in different tissues.