C
Cayetano Pleguezuelos-Manzano
Researcher at Royal Netherlands Academy of Arts and Sciences
Publications - 16
Citations - 898
Cayetano Pleguezuelos-Manzano is an academic researcher from Royal Netherlands Academy of Arts and Sciences. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 5, co-authored 11 publications receiving 322 citations. Previous affiliations of Cayetano Pleguezuelos-Manzano include University of Amsterdam.
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Journal ArticleDOI
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Cayetano Pleguezuelos-Manzano,Jens Puschhof,Axel Rosendahl Huber,Arne Van Hoeck,Henry M. Wood,Jason Nomburg,Jason Nomburg,Carino Gurjao,Carino Gurjao,Freek Manders,Guillaume Dalmasso,Paul B. Stege,Fernanda L. Paganelli,Maarten H. Geurts,Joep Beumer,Tomohiro Mizutani,Yi Miao,Reinier van der Linden,Stefan van der Elst,K. Christopher Garcia,Janetta Top,Rob J. L. Willems,Marios Giannakis,Marios Giannakis,Richard Bonnet,Phil Quirke,Matthew Meyerson,Edwin Cuppen,Ruben van Boxtel,Hans Clevers +29 more
TL;DR: A distinct mutational signature in colorectal cancer is described and it is implied that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.
Journal ArticleDOI
High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells
Joep Beumer,Jens Puschhof,Julia Bauzá-Martinez,Adriana Martinez-Silgado,Rasa Elmentaite,Kylie R. James,Alexander Ross,Delilah F. G. Hendriks,Benedetta Artegiani,Georg A. Busslinger,Bas Ponsioen,Amanda Andersson-Rolf,Aurelia Saftien,Charelle Boot,Kai Kretzschmar,Maarten H. Geurts,Yotam E. Bar-Ephraim,Cayetano Pleguezuelos-Manzano,Yorick Post,Harry Begthel,Franka H van der Linden,Carmen López-Iglesias,Willine J. van de Wetering,Willine J. van de Wetering,Reinier van der Linden,Peter J. Peters,Albert J. R. Heck,Joachim Goedhart,Hugo J. Snippert,Matthias Zilbauer,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Wei Wu,Hans Clevers +34 more
TL;DR: An organoid-based platform for functional studies of human EECs is described and several hormone-like molecules were identified, including hormones, sensory receptors, and transcription factors.
Journal ArticleDOI
Intestinal organoid cocultures with microbes.
Jens Puschhof,Cayetano Pleguezuelos-Manzano,Adriana Martinez-Silgado,Ninouk Akkerman,Aurelia Saftien,Charelle Boot,Amy de Waal,Joep Beumer,Devanjali Dutta,Devanjali Dutta,Inha Heo,Inha Heo,Hans Clevers +12 more
TL;DR: In this paper, the authors provide detailed protocols for characterizing the coculture with regard to bacterial and organoid cell viability and growth kinetics, as well as considerations for assessing the impact of bacteria on gene expression and mutations through RNA and DNA sequencing.
Journal ArticleDOI
Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells.
Cayetano Pleguezuelos-Manzano,Jens Puschhof,Stieneke van den Brink,Veerle Geurts,Joep Beumer,Hans Clevers +5 more
TL;DR: The protocols described in this article provide a basic guide to establishment and maintenance of human intestinal organoids derived from small intestine and colon biopsies.
Journal ArticleDOI
Organoids and organs-on-chips: Insights into human gut-microbe interactions.
TL;DR: A review of recent advances in the co-culture of microbes with intestinal and colonic epithelia, comparing the rapidly developing fields of organoids and organs-on-chips with other standard models can be found in this paper.