D
Douglas G. Osborne
Researcher at Mayo Clinic
Publications - 21
Citations - 635
Douglas G. Osborne is an academic researcher from Mayo Clinic. The author has contributed to research in topics: T cell & Retromer. The author has an hindex of 10, co-authored 16 publications receiving 424 citations. Previous affiliations of Douglas G. Osborne include University of Colorado Denver & University of Colorado Boulder.
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Journal ArticleDOI
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
Christine A. Phillips-Krawczak,Amika Singla,Petro Starokadomskyy,Z. Deng,Douglas G. Osborne,Haiying Li,Christopher J. Dick,Timothy S. Gomez,Megan Koenecke,Jin San Zhang,Jin San Zhang,Haiming Dai,Luis Sifuentes-Dominguez,Linda Geng,Scott H. Kaufmann,Marco Y. Hein,Mathew Wallis,Julie McGaughran,Julie McGaughran,Jozef Gecz,Jozef Gecz,Bart van de Sluis,Daniel D. Billadeau,Ezra Burstein +23 more
TL;DR: The COMMD1 protein, implicated in copper homeostasis, is found to regulate endosomal sorting of the copper transporter ATP7A through a novel protein complex containing CCDC22, CCDC93, and C16orf62, which link COM MD1 to the WASH complex.
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Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Da Jia,Da Jia,Jin San Zhang,Jin San Zhang,Fang Li,Jing Wang,Z. Deng,Z. Deng,Mark A. White,Douglas G. Osborne,Christine A. Phillips-Krawczak,Timothy S. Gomez,Haiying Li,Amika Singla,Ezra Burstein,Daniel D. Billadeau,Michael K. Rosen,Michael K. Rosen +17 more
TL;DR: It is demonstrated that TBC1d5, a GTPase-activating protein (GAP) for Rab7, is a high-affinity ligand of the retromer cargo selective complex VPS26/V PS29/VPS35.
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CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma
Dinoop Ravindran Menon,Yuchun Luo,John J. Arcaroli,Sucai Liu,Lekha Nair KrishnanKutty,Douglas G. Osborne,Yang Li,Jenny Mae Samson,Stacey M. Bagby,Aik Choon Tan,William A. Robinson,Wells A. Messersmith,Mayumi Fujita,Mayumi Fujita +13 more
TL;DR: Analysis of patient-derived xenografts from melanoma, colon, and pancreatic cancer tissues reveals a previously unrecognized role for CDK1 in regulating tumor-initiating capacity in melanoma and suggests a novel treatment strategy in cancer via interruption ofCDK1 function and its protein-protein interactions.
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Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion
Isak W. Tengesdal,Isak W. Tengesdal,Dinoop Ravindran Menon,Douglas G. Osborne,Charles Preston Neff,Nicholas E. Powers,Fabia Gamboni,Adolfo G Mauro,Angelo D'Alessandro,Davide Stefanoni,Morkos A. Henen,Morkos A. Henen,Taylor S. Mills,Dennis M. de Graaf,Dennis M. de Graaf,Tania Azam,Beat Vögeli,Brent E. Palmer,Eric M. Pietras,James DeGregori,Aik Choon Tan,Leo A. B. Joosten,Mayumi Fujita,Charles A. Dinarello,Charles A. Dinarello,Carlo Marchetti +25 more
TL;DR: In this paper, the formation of the pyrin domain-containing-3 (NLRP3) inflammasome activation in melanoma is linked to IL-1β production, inflammation, and immunosuppression.
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Trogocytosis Results in Sustained Intracellular Signaling in CD4 + T Cells
TL;DR: These novel findings suggest that trogocytosed molecules continue to engage their receptors on the T cell surface and sustain intracellular signaling leading to selective survival of these cells.