J.C. Chen

TL;DR: It is demonstrated that the intact dermal papilla transcriptional signature can be partially restored by growth of papilla cells in 3D spheroid cultures, and it is shown that human dermal Papilla cells, when grown as spheroids, are capable of inducing de novo hair follicles in human skin.

TL;DR: At the dose and duration studied, tofacitinib is a safe and effective treatment for severe AA, though it does not result in a durable response.

TL;DR: This work proposed a framework for the systematic discovery of genetic alterations that are causal determinants of disease, by prioritizing genes upstream of functional disease drivers, within regulatory networks inferred de novo from experimental data, and tested this framework by identifying the genetic determinant of the mesenchymal subtype of glioblastoma.

TL;DR: It is shown that topical treatment of mouse and human skin with small-molecule inhibitors of the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway results in rapid onset of anagen and subsequent hair growth.

TL;DR: 3D printed molds are used to pattern hair follicle cell types in a physiological organization, and achieve human hair growth on the back of a mouse.