J
Jacob M. Daane
Researcher at Northeastern University
Publications - 21
Citations - 441
Jacob M. Daane is an academic researcher from Northeastern University. The author has contributed to research in topics: Zebrafish & Convergent evolution. The author has an hindex of 8, co-authored 17 publications receiving 303 citations. Previous affiliations of Jacob M. Daane include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
Bioelectric Signaling Regulates Size in Zebrafish Fins
Simon Perathoner,Jacob M. Daane,Ulrike Henrion,Guiscard Seebohm,Charles W. Higdon,Stephen L. Johnson,Christiane Nüsslein-Volhard,Matthew P. Harris +7 more
TL;DR: It is shown that alf mutants carry gain-of-function mutations in kcnk5b, a gene encoding a two-pore domain potassium (K+) channel that requires the ability to conduct K+ ions to increase the size of these structures.
Journal ArticleDOI
Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form
Katrin Henke,Katrin Henke,Jacob M. Daane,Jacob M. Daane,M. Brent Hawkins,M. Brent Hawkins,Christopher M. Dooley,Elisabeth M. Busch-Nentwich,Elisabeth M. Busch-Nentwich,Derek L. Stemple,Matthew P. Harris,Matthew P. Harris +11 more
TL;DR: To understand the genetic control of postembryonic development, a dominant screen for phenotypes affecting the adult zebrafish is performed and mutational analysis suggests that there are key genes and pathways associated with late development.
Journal ArticleDOI
Historical contingency shapes adaptive radiation in Antarctic fishes
Jacob M. Daane,Alex Dornburg,Patrick Smits,Daniel J. MacGuigan,M. Brent Hawkins,M. Brent Hawkins,Thomas J. Near,Thomas J. Near,H. William Detrich,Matthew P. Harris,Matthew P. Harris +10 more
TL;DR: Phylogenetic comparative analysis of Antarctic notothenioid fishes reveals a burst of genomic diversification and evolution of key skeletal modifications before the onset of polar conditions in the Southern Ocean.
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Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin.
Jacob M. Daane,Jennifer Lanni,Jennifer Lanni,Ina Rothenberg,Guiscard Seebohm,Charles W. Higdon,Stephen L. Johnson,Matthew P. Harris +7 more
TL;DR: This work proposes that the interaction between Kcnk5b and calcineurin acts as a signaling node to regulate allometric growth, and finds that this regulation is epistatic to inherent mechanisms instructing overall size as inhibition of calcineURin is able to bypass genetic instruction of size as seen in sof and wild-type fins.
Journal ArticleDOI
Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies
Jacob M. Daane,Nicolas Rohner,Peter Konstantinidis,Sergej Djuranovic,Matthew P. Harris,Matthew P. Harris +5 more
TL;DR: A new comparative genomic approach is presented that can be applied to a broad taxonomic sampling of nonmodel species to investigate the genetic basis of evolutionary change and reveals epistatic interactions between fgfr1a and fgf20a as a developmental mechanism regulating skeletal variation among fishes.