S
Sergej Djuranovic
Researcher at Washington University in St. Louis
Publications - 33
Citations - 3215
Sergej Djuranovic is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Messenger RNA & Translation (biology). The author has an hindex of 19, co-authored 33 publications receiving 2860 citations. Previous affiliations of Sergej Djuranovic include Technische Universität München & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
The genome of Tetranychus urticae reveals herbivorous pest adaptations
Miodrag Grbic,Miodrag Grbic,Thomas Van Leeuwen,Richard M. Clark,Stephane Rombauts,Pierre Rouzé,Vojislava Grbic,Vojislava Grbic,Edward J. Osborne,Wannes Dermauw,Phuong Cao Thi Ngoc,Félix Ortego,Pedro Hernández-Crespo,Isabel Diaz,Manuel Martinez,Maria Navajas,Élio Sucena,Élio Sucena,Sara Magalhães,Lisa M. Nagy,Ryan M. Pace,Sergej Djuranovic,Guy Smagghe,Masatoshi Iga,Olivier Christiaens,Jan A. Veenstra,John Ewer,Rodrigo Mancilla Villalobos,Jeffrey L. Hutter,Stephen D. Hudson,Marisela Vélez,Marisela Vélez,Soojin V. Yi,Jia Zeng,Andre Pires-daSilva,Fernando Roch,Marc Cazaux,Marie Navarro,Vladimir Zhurov,Gustavo Acevedo,Anica Bjelica,Jeffrey A. Fawcett,Jeffrey A. Fawcett,Eric Bonnet,Eric Bonnet,Cindy Martens,Guy Baele,Lothar Wissler,Aminael Sánchez-Rodríguez,Luc Tirry,Catherine Blais,Kristof Demeestere,Stefan R. Henz,T. Ryan Gregory,Johannes Mathieu,Lou Verdon,Laurent Farinelli,Jeremy Schmutz,Erika Lindquist,René Feyereisen,Yves Van de Peer +60 more
TL;DR: The Tetranychus urticae genome is the smallest known arthropod genome as discussed by the authors, which represents the first complete chelicerate genome for a pest and has been annotated with genes associated with feeding on different hosts.
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miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay
TL;DR: The kinetics of these events in miRNA-mediated gene silencing are investigated by using a Drosophila S2 cell-based controllable expression system and show that mRNAs with both natural and engineered 3′ untranslated regions with miRNA target sites are first subject to translational inhibition, followed by effects on deadenylation and decay.
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A Parsimonious Model for Gene Regulation by miRNAs
TL;DR: More systematic analyses of the molecular specificities of the core components coupled with analysis of the relative timing of the different events will ultimately shed light on the mechanism of miRNA-mediated repression.
Journal ArticleDOI
Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases.
Sergej Djuranovic,Marcus D. Hartmann,Michael Habeck,Astrid Ursinus,Peter Zwickl,Jörg Martin,Andrei N. Lupas,Kornelius Zeth +7 more
TL;DR: The structures suggest a molecular mechanism for substrate processing based on concerted radial motions of the coiled coilsrelative to the OB rings relative to the N domains of an archaeal proteasomal ATPase.
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Ribosomes slide on lysine-encoding homopolymeric A stretches
Kristin S. Koutmou,Anthony P Schuller,Julie L. Brunelle,Julie L. Brunelle,Aditya Radhakrishnan,Sergej Djuranovic,Rachel Green +6 more
TL;DR: It is shown that mRNAs encoding iterated lysine codons, AAA or AAG, differentially impact protein synthesis: insertion of iterated AAA codons into an ORF diminishes protein expression more than insertion of synonymous AAG codons.