Jacqueline M. Slavik

TL;DR: It is shown that liCTLA-4 is expressed as a protein in primary T cells and strongly inhibits T cell responses by binding and dephosphorylating the TcRzeta chain, suggesting that increased expression and negative signaling delivered by the liCTla-4 may regulate development of T cell-mediated autoimmune diseases.

TL;DR: Lymphoblastoid cell lines are a promising model for pharmacogenetic experiments, but biological noise and in vitro artifacts may reduce power and have the potential to create spurious association due to confounding.

TL;DR: It is shown that expression of Tim-4 protein is restricted to CD11c+ and CD11b+ cells and is up-regulated upon activation and specifically phosphorylates Tim-1 and induces T cell expansion by enhancing cell division and reducing apoptosis.

TL;DR: Surprisingly, a heterogeneous proliferative response in the presence of rapamycin was observed among different Ag-specificCD8+ T cell clones; this was also observed in CD8+ peripheral blood T cells activated with TCR cross-linking ex vivo.

TL;DR: The selective immunosuppressive effect of rapamycin in human CD8+ T cell populations could be predictive of a selective effect allowing cytotoxic responses during microbial infections where there are strong strengths of signals associated with high affinity T cell receptors and strong costimulatory second signals.