J
Jae-Kyun Ko
Researcher at Rutgers University
Publications - 37
Citations - 1722
Jae-Kyun Ko is an academic researcher from Rutgers University. The author has contributed to research in topics: Ryanodine receptor & Skeletal muscle. The author has an hindex of 18, co-authored 31 publications receiving 1528 citations. Previous affiliations of Jae-Kyun Ko include University of Medicine and Dentistry of New Jersey & New Generation University College.
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Journal ArticleDOI
MG53 nucleates assembly of cell membrane repair machinery
Chuanxi Cai,Haruko Masumiya,Noah Weisleder,Noriyuki Matsuda,Miyuki Nishi,Moonsun Hwang,Jae-Kyun Ko,Pei-Hui Lin,Angela Thornton,Xiaoli Zhao,Zui Pan,Shinji Komazaki,Marco Brotto,Hiroshi Takeshima,Jianjie Ma +14 more
TL;DR: It is reported that MG53, a muscle-specific tripartite motif family protein (TRIM72), is a component of the sarcolemmal membrane-repair machinery and that MG 53 may initiate the assembly of the membrane repair machinery in an oxidation-dependent manner.
Journal ArticleDOI
Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction between MG53, Caveolin-3, and Dysferlin
Chuanxi Cai,Noah Weisleder,Jae-Kyun Ko,Shinji Komazaki,Yoshihide Sunada,Miyuki Nishi,Hiroshi Takeshima,Jianjie Ma +7 more
TL;DR: The data reveal that a molecular complex formed by MG53, dysferlin, and Cav3 is essential for repair of muscle membrane damage and also provide a therapeutic target for treatment of muscular and cardiovascular diseases that are linked to compromised membrane repair.
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Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans
Andrew P. Landstrom,Noah Weisleder,Karin B. Batalden,J. Martijn Bos,David J. Tester,Steve R. Ommen,Xander H.T. Wehrens,William C. Claycomb,Jae-Kyun Ko,Moonsun Hwang,Zui Pan,Jianjie Ma,Michael J. Ackerman +12 more
TL;DR: The molecular and functional evidence implicates defective junctophilin-2 and disrupted calcium signaling as a novel pathogenic mechanism for HCM and establishes HCM as the first human disease associated with genetic defects in JPH2.
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Exosomes: a new delivery system for tumor antigens in cancer immunotherapy.
J. Y. Cho,Dong-Jun Yeo,Hye-Youn Son,Hyun-Wha Kim,Dae-Sun Jung,Jae-Kyun Ko,Jason S. Koh,Yong-Nyun Kim,Chul Woo Kim +8 more
TL;DR: The data suggest that exosomes can be engineered from tumor cell lines to deliver a target immunogen capable of inducing an effective immune response and that they may represent a new cell‐free tumor vaccine.
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Parathyroid Hormone Uses Multiple Mechanisms to Arrest the Cell Cycle Progression of Osteoblastic Cells from G1 to S Phase
TL;DR: It is demonstrated that PTH regulates the expression of at least three genes to achieve the following: inducing expression of MAPK phosphatase 1 (MKP-1) and p21Cip1 and decreasing expression of cyclin D1 at both mRNA and protein levels.