Jaehwi Lee

TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.

TL;DR: The aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design.

TL;DR: A considerably reduced crystallinity of CLC dispersed in the PC-based dispersion formulations was demonstrated, which would be useful for improving the oral bioavailability of poorly soluble drugs such as CLC.

TL;DR: Detailed BAY-pharmacological target pathways were further characterized to determine how this compound simultaneously suppresses various responses and suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs withmultiple targets in inflammatory responses.

TL;DR: The results suggest that RGAP can activate macrophage function through activation of transcription factors such as NF-κB and AP-1 and their upstream signaling enzymes such as ERK and JNK and that TLR2 seems to be a target surface receptor of RGAP.