J
Jaehwi Lee
Researcher at Chung-Ang University
Publications - 158
Citations - 4657
Jaehwi Lee is an academic researcher from Chung-Ang University. The author has contributed to research in topics: Kinase & Tumor necrosis factor alpha. The author has an hindex of 31, co-authored 156 publications receiving 3913 citations.
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Journal ArticleDOI
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
Prakash Khadka,Jieun Ro,Hyeongmin Kim,Iksoo Kim,Jeong Tae Kim,Hyun-Il Kim,Jae Min Cho,Gyiae Yun,Jaehwi Lee +8 more
TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.
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Thin films as an emerging platform for drug delivery
TL;DR: The aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design.
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Enhancement of Aqueous Solubility and Dissolution of Celecoxib through Phosphatidylcholine-Based Dispersion Systems Solidified with Adsorbent Carriers
TL;DR: A considerably reduced crystallinity of CLC dispersed in the PC-based dispersion formulations was demonstrated, which would be useful for improving the oral bioavailability of poorly soluble drugs such as CLC.
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BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
TL;DR: Detailed BAY-pharmacological target pathways were further characterized to determine how this compound simultaneously suppresses various responses and suggest that BAY is an inhibitor with multiple targets and could serve as a lead compound in developing strong anti-inflammatory drugs withmultiple targets in inflammatory responses.
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Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red Ginseng
Se Eun Byeon,Jaehwi Lee,Ji Hye Kim,Woo Seok Yang,Yi-Seong Kwak,Sun Young Kim,Eui Su Choung,Man Hee Rhee,Jae Youl Cho +8 more
TL;DR: The results suggest that RGAP can activate macrophage function through activation of transcription factors such as NF-κB and AP-1 and their upstream signaling enzymes such as ERK and JNK and that TLR2 seems to be a target surface receptor of RGAP.