J
James Alexis Platts
Researcher at Cardiff University
Publications - 241
Citations - 7776
James Alexis Platts is an academic researcher from Cardiff University. The author has contributed to research in topics: Hydrogen bond & Density functional theory. The author has an hindex of 42, co-authored 231 publications receiving 7152 citations. Previous affiliations of James Alexis Platts include University of South Australia & Aarhus University.
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Correlation and prediction of critical micelle concentration using polar surface area and LFER methods
TL;DR: In this article, the linear free energy relationship of Abraham and a modified polar surface area approach were used to calculate critical micelle concentration (CMC) for anionic, non-ionic and structurally diverse molecules, including many commercially important drugs such as analgesics, anaesthetic and antibiotics.
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Tuning the Electronics of Phosphorescent, Amide‐Functionalized, Cyclometalated IrIII Complexes: Syntheses, Structures, Spectroscopy and Theoretical Studies
Jack D. Routledge,Andrew Jon Hallett,James Alexis Platts,Peter N. Horton,Simon J. Coles,Simon J. A. Pope +5 more
TL;DR: In this paper, single crystal X-ray diffraction studies were undertaken on two Iridium(III) complexes, which showed that each adopts a distorted octahedral coordination geometry with retention of the expected trans-N, cis-C arrangement of the cyclometalated ligands.
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Aryl azide photochemistry in defined protein environments.
Josephine Lydia Morris,Samuel C. Reddington,Damien Martin Murphy,D. Dafydd Jones,James Alexis Platts,Eric Michael Tippmann +5 more
TL;DR: A genetically encoded precursor to an aryl nitrene, para-azidophenylalanine, was introduced site specifically into proteins to deduce if distinct environments were capable of caging a reactive organic intermediate.
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A combined NMR and molecular dynamics simulation study to determine the conformational properties of agonists and antagonists against experimental autoimmune encephalomyelitis.
Efthimia D. Mantzourani,Klemen Blokar,Theodore Tselios,John Matsoukas,James Alexis Platts,Thomas Mavromoustakos,Simona Golic Grdadolnik +6 more
TL;DR: A robust method, which is based on a combination of molecular dynamics and energy minimization, is proposed for identifying the putative bioactive conformations of the EAE inducing epitope MBP and the structural motif for the agonist-antagonist activity is discussed.
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Design and Synthesis of Non-Peptide Mimetics Mapping the Immunodominant Myelin Basic Protein (MBP83-96) Epitope to Function as T-Cell Receptor Antagonists.
Mary-Patricia Yannakakis,Carmen Simal,Haralambos Tzoupis,Maria Rodi,Narges Dargahi,Monica D. Prakash,Athanasia Mouzaki,James Alexis Platts,Vasso Apostolopoulos,Theodore Tselios +9 more
TL;DR: These studies show that lead compounds 15 and 16 may be used for immunotherapy against MS and are able to inhibit to some extent the stimulation of T cells by the immunodominant MBP83–99 peptide from immunized mice.