J
James F.A. Poulet
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 53
Citations - 4575
James F.A. Poulet is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Sensory system & Barrel cortex. The author has an hindex of 30, co-authored 47 publications receiving 3801 citations. Previous affiliations of James F.A. Poulet include University of Cambridge & MIND Institute.
Papers
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Journal ArticleDOI
Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
TL;DR: It is shown that an internal brain state dynamically regulates cortical membrane potential synchrony during behaviour and defines different modes of cortical processing in behaving mice.
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Experimental evidence for sparse firing in the neocortex.
TL;DR: Overall, the firing output of granular and infragranular layers is highest and subthreshold activity across supragranular neurons is decidedly non-sparse, spikes are much less frequent and some cells are silent.
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Barrel cortex function
Dirk Feldmeyer,Michael Brecht,Fritjof Helmchen,Carl C.H. Petersen,James F.A. Poulet,Jochen F. Staiger,Heiko J. Luhmann,Cornelius Schwarz +7 more
TL;DR: It is argued that in order to understand neocortical function one needs to combine a microscopic view, elucidating the workings of the local columnar microcircuits, with a macroscopic view, which keeps track of the linkage of distant cortical modules in different behavioral contexts.
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Thalamic control of cortical states.
TL;DR: It is demonstrated that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can be mimicked by optogenetic stimulation of the thalamus, which is key in controlling cortical states.
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Synaptic Mechanisms Underlying Sparse Coding of Active Touch
Sylvain Crochet,Sylvain Crochet,James F.A. Poulet,James F.A. Poulet,James F.A. Poulet,Yves Kremer,Carl C.H. Petersen +6 more
TL;DR: Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood, and sparse coding appears to robustly signal each active touch response.