Journal ArticleDOI
Thalamic control of cortical states.
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TLDR
It is demonstrated that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can be mimicked by optogenetic stimulation of the thalamus, which is key in controlling cortical states.Abstract:
We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.read more
Citations
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The theta-gamma neural code
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TL;DR: Evidence is reviewed for the following hypothesis: that the dual oscillations form a code for representing multiple items in an ordered way, and that this coding scheme coordinates communication between brain regions and is involved in sensory as well as memory processes.
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Optogenetics: 10 years of microbial opsins in neuroscience
TL;DR: This Historical Commentary reflects on the scientific landscape of this decade-long transition between microbial opsin engineering and modular genetic methods for cell-type targeting, with the publication of thousands of discoveries and insights into the function of nervous systems and beyond.
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Diaschisis: past, present, future.
Emmanuel Carrera,Giulio Tononi +1 more
TL;DR: The development of new imaging techniques allows a better understanding of the complexity of brain organization and it is now possible to reliably investigate a new type of diaschisis defined as the changes of structural and functional connectivity between brain areas distant to the lesion.
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Network abnormalities and interneuron dysfunction in Alzheimer disease
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TL;DR: The concept that modulating these mechanisms may help to improve brain function in Alzheimer disease and related disorders is explored.
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Neuromodulation of Brain States
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TL;DR: Current understanding of the key neural circuits involved in regulating brain states, with a particular emphasis on the subcortical neuromodulatory systems are summarized.
References
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Journal ArticleDOI
Neuronal Oscillations in Cortical Networks
György Buzsáki,Andreas Draguhn +1 more
TL;DR: Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.
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Millisecond-timescale, genetically targeted optical control of neural activity.
TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
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Über das Elektrenkephalogramm des Menschen
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Modulation of Visual Responses by Behavioral State in Mouse Visual Cortex
TL;DR: The response properties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating spherical treadmill with their heads fixed demonstrated powerful cell-type-specific modulation of visual processing by behavioral state in awake mice.
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Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice
TL;DR: It is shown that an internal brain state dynamically regulates cortical membrane potential synchrony during behaviour and defines different modes of cortical processing in behaving mice.