J
James L. Alexander
Researcher at Imperial College London
Publications - 78
Citations - 1724
James L. Alexander is an academic researcher from Imperial College London. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 37 publications receiving 972 citations. Previous affiliations of James L. Alexander include St Mary's Hospital & Imperial College Healthcare.
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Journal ArticleDOI
Gut microbiota modulation of chemotherapy efficacy and toxicity
James L. Alexander,James L. Alexander,Ian D. Wilson,Julian Teare,Julian R. Marchesi,Jeremy K. Nicholson,James Kinross,James Kinross +7 more
TL;DR: The implications of pharmacomicrobiomics in cancer therapeutics are outlined and how the microbiota might be modified in clinical practice to improve efficacy and reduce the toxic burden of these compounds are defined.
Journal ArticleDOI
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.
Alasdair Scott,James L. Alexander,Claire A Merrifield,David Cunningham,Christian Jobin,Robert S. Brown,John C. Alverdy,Stephen J. O'Keefe,H. Rex Gaskins,Julian Teare,Jun Yu,David J. Hughes,Hans Verstraelen,Jeremy P. Burton,Paul W. O'Toole,Daniel W. Rosenberg,Julian R. Marchesi,James Kinross +17 more
TL;DR: In this paper, an international panel of experts delivered their opinions on key questions concerning the contribution of the human microbiome to carcinogenesis, including the relevance of dysbiosis/analtered gut, potential mechanisms of microbiota-induced carcinogenesis and future directions for research in the field.
Journal ArticleDOI
SARS-CoV-2 vaccination for patients with inflammatory bowel disease: a British Society of Gastroenterology Inflammatory Bowel Disease section and IBD Clinical Research Group position statement.
James L. Alexander,James L. Alexander,Gordon W. Moran,Daniel R. Gaya,Daniel R. Gaya,Tim Raine,Ailsa Hart,Nicholas A. Kennedy,James O. Lindsay,James O. Lindsay,Jonathan Macdonald,Jonathan Segal,Jonathan Segal,Shaji Sebastian,Christian P. Selinger,Miles Parkes,Philip J Smith,Anjan Dhar,Sreedhar Subramanian,Ramesh P. Arasaradnam,Christopher A. Lamb,Christopher A. Lamb,Tariq Ahmad,Charlie W. Lees,Charlie W. Lees,L Dobson,Ruth Wakeman,Tariq Iqbal,Ian D. Arnott,Nick Powell,Nick Powell,Christine Norton,Shahida Din,Jackie Glatter,Jochen Kammermeier,Madhoor Ramdeen,Nabil Quraishi,Peter Sagar,Shellie Jean Radford,R. Alexander Speight,Helen Steed,Michael McFarlane,A Barney Hawthorne +42 more
TL;DR: In this article, a position statement endorsed by the British Society of Gastroenterology Inflammatory Bowel Disease (IBD) section and IBD Clinical Research Group, considers SARS-CoV-2 vaccination strategy in patients with IBD.
Journal ArticleDOI
In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)
Julia Balog,Sacheen Kumar,James L. Alexander,Ottmar Golf,Juzheng Huang,Tom Wiggins,Nima Abbassi-Ghadi,Attila Enyedi,Sandor Kacska,James Kinross,George B. Hanna,Jeremy K. Nicholson,Zoltan Takats +12 more
TL;DR: Rapid evaporative ionization mass spectrometry (REIMS) was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.
Journal ArticleDOI
A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife
James L. Alexander,Louise Gildea,Julia Balog,Abigail Speller,James S. McKenzie,Laura J. Muirhead,Alasdair Scott,Christos Kontovounisios,Shanawaz Rasheed,Julian Teare,Jonathan Hoare,Kirill Veselkov,Robert D. Goldin,Paris Tekkis,Ara Darzi,Jeremy K. Nicholson,James Kinross,Zoltan Takats +17 more
TL;DR: REIMS demonstrates high diagnostic accuracy for tumor type and for established histological features of poor prognostic outcome in CRC based on a multivariate analysis of the mucosal lipidome and could augment endoscopic and imaging technologies for precision phenotyping of colorectal cancer.