P
Paul W. O'Toole
Researcher at University College Cork
Publications - 313
Citations - 34637
Paul W. O'Toole is an academic researcher from University College Cork. The author has contributed to research in topics: Gut flora & Microbiome. The author has an hindex of 78, co-authored 295 publications receiving 26443 citations. Previous affiliations of Paul W. O'Toole include Teagasc & Lund University.
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Journal ArticleDOI
Gut microbiota composition correlates with diet and health in the elderly
Marcus J. Claesson,Ian B. Jeffery,Susana Conde,Susan E. Power,Eibhlís M. O'Connor,Siobhán Cusack,Hugh M. B. Harris,M. Coakley,Bhuvaneswari Lakshminarayanan,Orla O'Sullivan,Gerald F. Fitzgerald,Jennifer Deane,Michael O'Connor,Norma Harnedy,Kieran O'Connor,Denis O'Mahony,Denis O'Mahony,Douwe van Sinderen,Martina Wallace,Lorraine Brennan,Catherine Stanton,Catherine Stanton,Julian R. Marchesi,Anthony P. Fitzgerald,Fergus Shanahan,Colin Hill,R. Paul Ross,R. Paul Ross,Paul W. O'Toole +28 more
TL;DR: The data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.
Journal ArticleDOI
A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae.
Jinshui Zheng,Stijn Wittouck,Elisa Salvetti,Charles M. A. P. Franz,Hugh M. B. Harris,Paola Mattarelli,Paul W. O'Toole,Bruno Pot,Peter Vandamme,Jens Walter,Koichi Watanabe,Sander Wuyts,Giovanna E. Felis,Michael G. Gänzle,Michael G. Gänzle,Sarah Lebeer +15 more
TL;DR: This study evaluated the taxonomy of Lactobacillaceae and Leuconostocaceae on the basis of whole genome sequences and proposed reclassification reflects the phylogenetic position of the micro-organisms, and groups lactobacilli into robust clades with shared ecological and metabolic properties.
Journal ArticleDOI
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Marcus J. Claesson,Siobhán Cusack,Orla O'Sullivan,Rachel Greene-Diniz,Heleen de Weerd,E. Flannery,Julian R. Marchesi,Julian R. Marchesi,Daniel Falush,Timothy G. Dinan,Gerald F. Fitzgerald,Catherine Stanton,Catherine Stanton,Douwe van Sinderen,Michael O'Connor,Norma Harnedy,Kieran O'Connor,Colm Henry,Denis O'Mahony,Denis O'Mahony,Anthony P. Fitzgerald,Fergus Shanahan,C. Twomey,C. Twomey,Colin Hill,R. Paul Ross,R. Paul Ross,Paul W. O'Toole +27 more
TL;DR: It is concluded that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability.
Journal ArticleDOI
High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome.
Francesca De Filippis,Nicoletta Pellegrini,Lucia Vannini,Ian B. Jeffery,Antonietta La Storia,Luca Laghi,Diana Isabella Serrazanetti,Raffaella Di Cagno,Ilario Ferrocino,Camilla Lazzi,Silvia Turroni,Luca Simone Cocolin,Patrizia Brigidi,Erasmo Neviani,Marco Gobbetti,Paul W. O'Toole,Danilo Ercolini +16 more
TL;DR: High-level consumption of plant foodstuffs consistent with an MD is associated with beneficial microbiome-related metabolomic profiles in subjects ostensibly consuming a Western diet, as well as higher urinary trimethylamine oxide levels in individuals with lower adherence to the MD.
Journal ArticleDOI
Exercise and associated dietary extremes impact on gut microbial diversity
Siobhan F. Clarke,Siobhan F. Clarke,Eileen F. Murphy,Orla O'Sullivan,Alice J. Lucey,Margaret Humphreys,Aileen Hogan,Paula A. Hayes,O'Reilly M,Ian B. Jeffery,Ruth Wood-Martin,David M. Kerins,Eamonn Martin Quigley,R. Paul Ross,R. Paul Ross,Paul W. O'Toole,Michael G. Molloy,Eanna Falvey,Fergus Shanahan,Paul D. Cotter,Paul D. Cotter +20 more
TL;DR: Evidence is provided for a beneficial impact of exercise on gut microbiota diversity but also indicate that the relationship is complex and is related to accompanying dietary extremes.