John E. Mittler

TL;DR: It is demonstrated that CD8 cells play a crucial role in suppressing SIV replication in vivo and are examined using an anti-CD8 monoclonal antibody, OKT8F.

TL;DR: It is confirmed that HIV-1 and HCV are produced and cleared extremely rapidly, up to ten times higher than previous estimates, whereas HCV clearance is similar to previous estimates.

TL;DR: It is demonstrated here that the latent reservoir of HIV-1 decays with a mean half-life of 6.3 months in patients who consistently maintain plasma HIV- 1 RNA levels of fewer than 50 copies/ml, and in individuals who experience intermittent episodes of plasma viremia.

TL;DR: The data show that M. tuberculosis replicates throughout the course of chronic infection of mice and is restrained by the host immune system, and this approach may also shed light on the replication dynamics of other chronic pathogens.

TL;DR: It is suggested that bacterial intermixing is limited in CF lungs and that regional selective pressures may markedly differ, which may explain how specialized bacterial variants arise during infection and raise the possibility that pathogen diversification occurs in other chronic infections characterized by spatially heterogeneous conditions.