J
James W. Fawcett
Researcher at University of Cambridge
Publications - 357
Citations - 38704
James W. Fawcett is an academic researcher from University of Cambridge. The author has contributed to research in topics: Axon & Perineuronal net. The author has an hindex of 100, co-authored 350 publications receiving 35525 citations. Previous affiliations of James W. Fawcett include University of Sheffield & King's College London.
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Journal ArticleDOI
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials
James W. Fawcett,Armin Curt,John D. Steeves,William P. Coleman,Mark H. Tuszynski,Daniel P. Lammertse,Perry F. Bartlett,Andrew R. Blight,Volker Dietz,John F. Ditunno,Bruce H. Dobkin,Leif A. Havton,P H Ellaway,Michael G. Fehlings,A Privat,Robert G. Grossman,James D. Guest,Naomi Kleitman,Masaya Nakamura,M. Gaviria,D J Short +20 more
TL;DR: The spontaneous rate of recovery after SCI and resulting consequences for achieving statistically significant results in clinical trials are examined, based on previous data of the magnitude of spontaneous recovery afterSCI, as measured by changes in ASIA motor scores.
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The oligodendrocyte precursor cell in health and disease
TL;DR: Adult oligodendrocyte precursor cells make up around 5-8% of the glial cell population in the CNS, and their function in the undamaged CNS is largely unknown, but their processes are in contact with nodes of Ranvier and synapses, suggesting a regulatory role at these structures.
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Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.
TL;DR: It is demonstrated that it is possible to enhance CNS axon regeneration in the adult rat nigrostriatal tract following chondroitinase ABC degradation of chondDetroitin sulfate.
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The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system.
TL;DR: The development of methods to remove CSPGs has considerable therapeutic potential in a number of CNS disorders and may be involved in the pathological processes in diseases such as epilepsy, stroke and Alzheimer's disease.
Journal ArticleDOI
Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures
John D. Steeves,Daniel P. Lammertse,Armin Curt,James W. Fawcett,Mark H. Tuszynski,John F. Ditunno,P H Ellaway,Michael G. Fehlings,James D. Guest,Naomi Kleitman,Perry F. Bartlett,Andrew R. Blight,Volker Dietz,Bruce H. Dobkin,Robert G. Grossman,D J Short,Masaya Nakamura,William P. Coleman,M. Gaviria,A Privat +19 more
TL;DR: An international panel reviewed the methodology for clinical trials of spinal cord injury (SCI), and provided recommendations for the valid conduct of future trials, and focused on outcome measures that are relevant toclinical trials of experimental cell-based and pharmaceutical drug treatments.