J
James W. Fawcett
Researcher at University of Cambridge
Publications - 357
Citations - 38704
James W. Fawcett is an academic researcher from University of Cambridge. The author has contributed to research in topics: Axon & Perineuronal net. The author has an hindex of 100, co-authored 350 publications receiving 35525 citations. Previous affiliations of James W. Fawcett include University of Sheffield & King's College London.
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Journal ArticleDOI
Long Micro-Channel Electrode Arrays: A Novel Type of Regenerative Peripheral Nerve Interface
Stéphanie P. Lacour,James J. FitzGerald,Natalia Lago,E.J. Tarte,Stephen B. McMahon,James W. Fawcett +5 more
TL;DR: In this paper, micro-channel electrode arrays with 100 mum times 100 mum cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support Axon regeneration and vascularisation.
Journal ArticleDOI
The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?
TL;DR: The overall aim for successful regeneration is to ensure that the right molecules are expressed after axotomy and to arrange for them to be transported to the right place in the neuron, including the damaged axon tip.
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Challenges for defining minimal clinically important difference (MCID) after spinal cord injury
Xiaoliang Wu,Jie Liu,Lorenzo G. Tanadini,Daniel P. Lammertse,Andrew R. Blight,John L.K. Kramer,Giorgio Scivoletto,Linda Jones,Steven Kirshblum,Rainer Abel,James W. Fawcett,Edelle C. Field-Fote,James D. Guest,Ben Levinson,Doris Maier,Keith E. Tansey,Norbert Weidner,Wolfram Tetzlaff,Torsten Hothorn,Armin Curt,John D. Steeves +20 more
TL;DR: Estimation of an MCID for SCI remains elusive and if the target of a therapeutic is the injured spinal cord, it is most desirable that any improvement in neurological status be correlated with a functional (meaningful) benefit.
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Inosine promotes recovery of skilled motor function in a model of focal brain injury.
Justin M. Smith,Precious Lunga,David Story,Neil G. Harris,Janel E. Le Belle,Michael F James,John D. Pickard,James W. Fawcett +7 more
TL;DR: A new rat head injury model was developed, in which a computer-controlled impactor produced full thickness lesions of the forelimb region of the sensorimotor cortex, and inosine was infused into the lateral ventricles for 28 days to promote plasticity.
Journal ArticleDOI
NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature
M. Talal F. Al-Mayhani,Richard Grenfell,Masashi Narita,Sara Grazia Maria Piccirillo,Emma Kenney-Herbert,James W. Fawcett,Peter Collins,Koichi Ichimura,Colin Watts +8 more
TL;DR: This work identifies a GBM cell population (GBM NG2+ cells) with robust proliferative, clonogenic, and tumorigenic capacity and expresses NG2 by such an aggressive and actively cycling GBM population, identifying this cell population as a potential therapeutic target in a subset of patients with GBM.