J
James W. Fawcett
Researcher at University of Cambridge
Publications - 357
Citations - 38704
James W. Fawcett is an academic researcher from University of Cambridge. The author has contributed to research in topics: Axon & Perineuronal net. The author has an hindex of 100, co-authored 350 publications receiving 35525 citations. Previous affiliations of James W. Fawcett include University of Sheffield & King's College London.
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Journal ArticleDOI
ARF6 Directs Axon Transport and Traffic of Integrins and Regulates Axon Growth in Adult DRG Neurons
Richard Eva,Sarah Crisp,Jamie R. K. Marland,Jim C. Norman,Venkateswarlu Kanamarlapudi,Charles ffrench-Constant,James W. Fawcett +6 more
TL;DR: A novel mechanism of integrin traffic and transport in peripheral axons, regulated by the activation state of ARF6, is suggested, and it is suggested that ARF 6 might be targeted to enhance integrin-dependent axon regeneration after injury.
Journal ArticleDOI
Large animal and primate models of spinal cord injury for the testing of novel therapies
Brian K. Kwon,Femke Streijger,Caitlin E. Hill,Aileen J. Anderson,Mark Bacon,Michael S. Beattie,Armin Blesch,Elizabeth J. Bradbury,Arthur Brown,Jacqueline C. Bresnahan,Casey C. Case,Raymond W. Colburn,Samuel David,James W. Fawcett,Adam R. Ferguson,Itzhak Fischer,Candace L. Floyd,John C. Gensel,John D. Houle,Lyn B. Jakeman,Nick D. Jeffery,Linda Jones,Naomi Kleitman,Jeffery D. Kocsis,Paul Lu,David S.K. Magnuson,Martin Marsala,Simon W. Moore,Andrea J. Mothe,Martin Oudega,Giles W. Plant,Alexander Sasha Rabchevsky,Jan M. Schwab,Jerry Silver,Oswald Steward,Xiao Ming Xu,James D. Guest,Wolfram Tetzlaff +37 more
TL;DR: The results reveal that while many feel that large animal and primate models of SCI are valuable in the testing of novel therapies, important questions remain unanswered about how they should be used and how data derived from them should be interpreted.
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Microchannels as Axonal Amplifiers
TL;DR: It is demonstrated that confining axons in such channels substantially amplifies the extracellular signal, and a microchannel architecture seems well suited to the requirements of a peripheral nerve interface.
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Role of Chondroitin Sulfate Proteoglycans in Axonal Conduction in Mammalian Spinal Cord
Arsen S. Hunanyan,Guillermo García-Alías,Valentina Alessi,Joel M. Levine,James W. Fawcett,Lorne M. Mendell,Victor L. Arvanian +6 more
TL;DR: Results identify a novel acute action of CSPGs on axonal conduction in the spinal cord and suggest that antagonism of proteoglycans reverses or prevents the decline of axonal Conduction, in addition to stimulating axonal growth.
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Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice
TL;DR: The results suggest that, in response to brain injury, NG2+ progenitors may generate a subpopulation of astrocytes in addition to oligodendrocytic cells and their fate choice was associated with Olig2TL or Olig 2Nuc.