J
James W. Fawcett
Researcher at University of Cambridge
Publications - 357
Citations - 38704
James W. Fawcett is an academic researcher from University of Cambridge. The author has contributed to research in topics: Axon & Perineuronal net. The author has an hindex of 100, co-authored 350 publications receiving 35525 citations. Previous affiliations of James W. Fawcett include University of Sheffield & King's College London.
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Journal ArticleDOI
Neuronal Maturation: Challenges and Opportunities in a Nascent Field.
TL;DR: This work conceptualizes neuronal maturation as a research field that will have, it would argue, a strong impact on understanding the healthy and diseased nervous system.
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Bridging spinal cord injuries
TL;DR: One strategy for spinal cord injury repair is to make cellular bridges that support axon regeneration, however, the bridging cells often fail to integrate with host tissue and may lead to increased pain sensitivity.
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Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons
Jessica C. F. Kwok,Jessica C. F. Kwok,Ying Lai Yuen,Wai Kit Lau,Fu Xing Zhang,Fu Xing Zhang,James W. Fawcett,YS Chan,Daisy K.Y. Shum +8 more
TL;DR: 24-hour cultures of the rat embryos and chondroitinase ABC treatment of the hindbrain matrix are exploited to reveal the role of CS moieties in axonal initiation and projection in the early hindbrain and control the course and fasciculation of axonal projections and the timing ofAxonal arrival at the target.
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Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries
Philippa M Warren,Philippa M Warren,Melissa R. Andrews,Melissa R. Andrews,Marc Smith,Katalin Bartus,Elizabeth J. Bradbury,Joost Verhaagen,James W. Fawcett,James W. Fawcett,Jessica C. F. Kwok,Jessica C. F. Kwok +11 more
TL;DR: This study demonstrates the profound effect of the enzyme on cellular motility, growth and migration and provides in vitro evidence that mChABC gene therapy is equally or more effective at producing these effects as a one-time application of commercially available ChABC.