J
James W. Wilson
Researcher at Villanova University
Publications - 44
Citations - 2468
James W. Wilson is an academic researcher from Villanova University. The author has contributed to research in topics: Salmonella enterica & Gene. The author has an hindex of 20, co-authored 44 publications receiving 2185 citations. Previous affiliations of James W. Wilson include Tulane University & Arizona State University.
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Journal ArticleDOI
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq
James W. Wilson,C. M. Ott,K. Höner zu Bentrup,Rajee Ramamurthy,L. Quick,Steffen Porwollik,Pui Cheng,Michael McClelland,George Tsaprailis,Timothy R. Radabaugh,Andrea M. Hunt,D. Fernandez,Emily G. Richter,Miti Shah,Michelle Kilcoyne,Lokesh Joshi,Mayra Nelman-Gonzalez,S. Hing,Macarena Parra,P. Dumars,Kelly L.L. Norwood,R. Bober,J. Devich,A. Ruggles,Carla Goulart,Mark Rupert,Louis S. Stodieck,Phillip Stafford,L. Catella,Michael J. Schurr,Michael J. Schurr,Kent L. Buchanan,Kent L. Buchanan,Lisa A. Morici,James McCracken,James McCracken,Patricia L. Allen,Patricia L. Allen,C. Baker-Coleman,C. Baker-Coleman,Timothy G. Hammond,Timothy G. Hammond,Jörg Vogel,Randall W. Nelson,Duane L. Pierson,Heidemarie M. Stefanyshyn-Piper,C. A. Nickerson +46 more
TL;DR: Strategies to target Hfq and related regulators could potentially decrease infectious disease risks during space flight missions and provide novel therapeutic options on Earth.
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Microbial Responses to Microgravity and Other Low-Shear Environments
TL;DR: This review summarizes recent and future research trends aimed at understanding the dynamic effects of changes in the mechanical forces that occur in microgravity and other low-shear environments on a wide variety of important microbial parameters.
Journal ArticleDOI
Mechanisms of bacterial pathogenicity
James W. Wilson,Michael J. Schurr,C. L. LeBlanc,Rajee Ramamurthy,Kent L. Buchanan,Cheryl A. Nickerson +5 more
TL;DR: The availability of complete genome sequences for several bacterial pathogens coupled with bioinformatics will lead to significant advances toward the identification and characterisation of all these different strategies for bacterial disease.
Journal ArticleDOI
Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon
James W. Wilson,Rajee Ramamurthy,Steffen Porwollik,Michael McClelland,Timothy G. Hammond,Patricia L. Allen,C. Mark Ott,Duane L. Pierson,Cheryl A. Nickerson +8 more
TL;DR: DNA microarray results indicate that the ferric uptake regulator is involved in the LSMMG response and could provide clues for the functioning of known Salmonella virulence systems or the identification of uncharacterized bacterial virulence strategies.
Journal ArticleDOI
Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis.
Cheryl A. Nickerson,C. Mark Ott,James W. Wilson,Rajee Ramamurthy,C. L. LeBlanc,Kerstin Höner zu Bentrup,Timothy G. Hammond,Timothy G. Hammond,Duane L. Pierson +8 more
TL;DR: The use of microgravity technology to generate physiologically relevant human tissue models for research in bacterial pathogenesis and the response of bacteria to environmental signals, which are similar to those encountered during prokaryotic life cycles, are discussed.