M
Mayra Nelman-Gonzalez
Researcher at Wyle Laboratories
Publications - 31
Citations - 1493
Mayra Nelman-Gonzalez is an academic researcher from Wyle Laboratories. The author has contributed to research in topics: Spaceflight & Medicine. The author has an hindex of 16, co-authored 27 publications receiving 1204 citations. Previous affiliations of Mayra Nelman-Gonzalez include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq
James W. Wilson,C. M. Ott,K. Höner zu Bentrup,Rajee Ramamurthy,L. Quick,Steffen Porwollik,Pui Cheng,Michael McClelland,George Tsaprailis,Timothy R. Radabaugh,Andrea M. Hunt,D. Fernandez,Emily G. Richter,Miti Shah,Michelle Kilcoyne,Lokesh Joshi,Mayra Nelman-Gonzalez,S. Hing,Macarena Parra,P. Dumars,Kelly L.L. Norwood,R. Bober,J. Devich,A. Ruggles,Carla Goulart,Mark Rupert,Louis S. Stodieck,Phillip Stafford,L. Catella,Michael J. Schurr,Michael J. Schurr,Kent L. Buchanan,Kent L. Buchanan,Lisa A. Morici,James McCracken,James McCracken,Patricia L. Allen,Patricia L. Allen,C. Baker-Coleman,C. Baker-Coleman,Timothy G. Hammond,Timothy G. Hammond,Jörg Vogel,Randall W. Nelson,Duane L. Pierson,Heidemarie M. Stefanyshyn-Piper,C. A. Nickerson +46 more
TL;DR: Strategies to target Hfq and related regulators could potentially decrease infectious disease risks during space flight missions and provide novel therapeutic options on Earth.
Journal ArticleDOI
Media Ion Composition Controls Regulatory and Virulence Response of Salmonella in Spaceflight
James W. Wilson,C. Mark Ott,Laura N. Quick,Laura N. Quick,Richard R. Davis,Kerstin Höner zu Bentrup,Aurélie Crabbé,Emily G. Richter,Shameema Sarker,Jennifer Barrila,Steffen Porwollik,Pui Cheng,Michael McClelland,George Tsaprailis,Timothy R. Radabaugh,Andrea M. Hunt,Miti Shah,Mayra Nelman-Gonzalez,Steve Hing,Macarena Parra,Paula Dumars,Kelly L.L. Norwood,Ramona Bober,Jennifer Devich,Ashleigh Ruggles,Autumn CdeBaca,Satro Narayan,Joseph Benjamin,Carla Goulart,Mark Rupert,Luke Catella,Michael J. Schurr,Kent L. Buchanan,Lisa A. Morici,James McCracken,Marc D. Porter,Duane L. Pierson,Scott M. Smith,Max Mergeay,Natalie Leys,Heidemarie M. Stefanyshyn-Piper,Dominic Gorie,Cheryl A. Nickerson +42 more
TL;DR: It is reported that spaceflight-induced increases in Salmonella virulence are regulated by media ion composition, and that phosphate ion is sufficient to alter related pathogenesis responses in a spaceflight analogue model.
Journal ArticleDOI
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration.
Ebrahim Afshinnekoo,Ryan T. Scott,Matthew MacKay,Eloise Pariset,Eloise Pariset,Egle Cekanaviciute,Richard Barker,Simon Gilroy,Duane C. Hassane,Scott M. Smith,Sara R. Zwart,Mayra Nelman-Gonzalez,Brian Crucian,S. A. Ponomarev,Oleg Orlov,Dai Shiba,Masafumi Muratani,Masayuki Yamamoto,Stephanie E. Richards,Parag Vaishampayan,Cem Meydan,Jonathan Foox,Jacqueline Myrrhe,Eric Istasse,Nitin Kumar Singh,Kasthuri Venkateswaran,Jessica A. Keune,Hami E. Ray,Mathias Basner,Jack M. Miller,Jack M. Miller,Martha Hotz Vitaterna,Deanne Taylor,Deanne Taylor,Douglas C. Wallace,Douglas C. Wallace,Kathleen Rubins,Susan M. Bailey,Peter Grabham,Sylvain V. Costes,Christopher E. Mason,Afshin Beheshti,Afshin Beheshti +42 more
TL;DR: The known hazards of human spaceflight are reviewed, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration are discussed.
Journal ArticleDOI
Regulation of Cdc25C by ERK-MAP Kinases during the G2/M Transition
Ruoning Wang,Ruoning Wang,Guangan He,Mayra Nelman-Gonzalez,Cheryl L. Ashorn,Gary E. Gallick,P. Todd Stukenberg,Marc W. Kirschner,Jian Kuang +8 more
TL;DR: It is demonstrated that p42 MAP kinase (MAPK), the Xenopus ortholog of ERK2, is a major Cdc25 phosphorylating kinase in extracts of M phase-arrested Xenopus eggs and that ERK-MAP kinases are directly involved in activating CDC25 during the G(2)/M transition.
Journal ArticleDOI
Induction of Attachment-Independent Biofilm Formation and Repression of hfq Expression by Low-Fluid-Shear Culture of Staphylococcus aureus
TL;DR: Results suggest Staphylococcus aureus responds to a low-fluid-shear environment by initiating a biofilm/colonization phenotype with diminished virulence characteristics, which could lead to insight into key factors influencing the divergence between infection and colonization during the initial host-pathogen interaction.