Jan J. Weening

TL;DR: In this article, a new classification for IgA nephropathy is presented by an international consensus working group and the goal of this new system was to identify specific pathological features that more accurately predict risk of progression of renal disease.

TL;DR: A unique approach for the pathological classification of a glomerular disease, IgA nephropathy, is developed, in which renal pathologists first undertook extensive iterative work to define pathologic variables with acceptable inter-observer reproducibility.

TL;DR: Combining the MEST score with cross-sectional clinical data at biopsy provides earlier risk prediction in IgAN than current best methods, which requires clinical data over 2 years of follow-up.

TL;DR: The cross-sectional correlation between pathology and proteinuria was similar in adults and children and the predictive value of each specific lesion on the rate of decline of renal function or renal survival in IgA nephropathy was not different between children and adults.

TL;DR: A case of toxic acute tubular injury in a healthy 56-year-old female volunteer after a pharmacologically active dose of a locked nucleic acid antisense oligonucleotide was administered, and the patient recovered fully and kidney function was normal at every follow-up visit.