Michael G. Heckman

TL;DR: The proposed system for endoscopically-identified oesophageal features of EoE defines common nomenclature and severity scores for the assessment of EiE disease activity and has good interobserver agreement among practising and academic gastroenterologists.

TL;DR: The results for LRRK2 show that several rare and common genetic variants in the same gene can have independent effects on disease risk, and are important in the cause and pathogenesis of PD in a greater proportion of patients with this disease than previously believed.

TL;DR: The findings indicate that expansion size does affect disease severity, which--if replicated in other cohorts--could be relevant for genetic counselling.

TL;DR: Findings indicate that tracking poly(GP) proteins in CSF could provide a means to assess target engagement of G4C2 RNA–based therapies in symptomatic C9ORF72 repeat expansion carriers and presymptomatic individuals who are expected to benefit from early therapeutic intervention.

TL;DR: Confocal endomicroscopy demonstrated higher sensitivity with similar specificity in classification of colorectal polyps and may replace the need for ex vivo histological confirmation of small polyps, but further studies are warranted.