C
Christian Wider
Researcher at University of Lausanne
Publications - 72
Citations - 4268
Christian Wider is an academic researcher from University of Lausanne. The author has contributed to research in topics: Parkinsonism & Parkinson's disease. The author has an hindex of 31, co-authored 72 publications receiving 3856 citations. Previous affiliations of Christian Wider include University Hospital of Lausanne & Mayo Clinic.
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Journal ArticleDOI
VPS35 Mutations in Parkinson Disease
Carles Vilariño-Güell,Christian Wider,Owen A. Ross,Justus C. Dachsel,Jennifer M. Kachergus,Sarah Lincoln,Alexandra I. Soto-Ortolaza,Stephanie A. Cobb,Greggory J. Wilhoite,Justin A. Bacon,Behrouz Bahareh Behrouz,Heather L. Melrose,Emna Hentati,Andreas Puschmann,Andreas Puschmann,Daniel M. Evans,Elizabeth Conibear,Wyeth W. Wasserman,Jan O. Aasly,Pierre R. Burkhard,Ruth Djaldetti,Joseph Ghika,Fayçal Hentati,Anna Krygowska-Wajs,Timothy Lynch,Timothy Lynch,Eldad Melamed,Alex Rajput,Ali H. Rajput,Alessandra Solida,Ruey-Meei Wu,Ryan J. Uitti,Zbigniew K. Wszolek,François Vingerhoets,Matthew J. Farrer,Matthew J. Farrer +35 more
TL;DR: This study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD.
Journal ArticleDOI
Mutations in the colony stimulating factor 1 receptor ( CSF1R ) gene cause hereditary diffuse leukoencephalopathy with spheroids
Rosa Rademakers,Matt Baker,Alexandra M. Nicholson,Nicola J. Rutherford,Nicole A. Finch,Alexandra I. Soto-Ortolaza,Jennifer Lash,Christian Wider,Christian Wider,Aleksandra Wojtas,Mariely DeJesus-Hernandez,Jennifer Adamson,Naomi Kouri,Christina Sundal,Christina Sundal,Elizabeth A. Shuster,Jan O. Aasly,James MacKenzie,Sigrun Roeber,Hans A. Kretzschmar,Bradley F. Boeve,David S. Knopman,Ronald C. Petersen,Nigel J. Cairns,Bernardino Ghetti,Salvatore Spina,James Y. Garbern,Alexandros Tselis,Ryan J. Uitti,Pritam Das,Jay A. van Gerpen,James F. Meschia,Shawn Levy,Daniel F. Broderick,Neill R. Graff-Radford,Owen A. Ross,Bradley Miller,Russell H. Swerdlow,Dennis W. Dickson,Zbigniew K. Wszolek +39 more
TL;DR: It is suggested that HDLS may result from partial loss of CSF1R function, and an important role for microglial dysfunction in HDLS pathogenesis is suggested.
Journal ArticleDOI
Quantification of Tremor and Bradykinesia in Parkinson's Disease Using a Novel Ambulatory Monitoring System
TL;DR: Evidence is provided that objective, accurate and simultaneous assessment of tremor and bradykinesia can be achieved in free moving PD patients during their daily activities.
Journal ArticleDOI
DCTN1 mutations in Perry syndrome
Matthew J. Farrer,Mary M. Hulihan,Jennifer M. Kachergus,Justus C. Dachsel,A. Jon Stoessl,Linda L. Grantier,S. Calne,Donald B. Calne,Bernard Lechevalier,Françoise Chapon,Yoshio Tsuboi,Tatsuo Yamada,Ludwig Gutmann,Bulent Elibol,Kailash P. Bhatia,Christian Wider,Carles Vilariño-Güell,Owen A. Ross,L. Brown,Monica Castanedes-Casey,Dennis W. Dickson,Zbigniew K. Wszolek +21 more
TL;DR: The findings show that DCTN1 mutations, previously associated with motor neuron disease, can underlie the selective vulnerability of other neuronal populations in distinct neurodegenerative disorders.
Journal ArticleDOI
CSF1R mutations link POLD and HDLS as a single disease entity.
Alexandra M. Nicholson,Matt Baker,Ni Cole A. Finch,Nicola J. Rutherford,Christian Wider,Christian Wider,Neill R. Graff-Radford,Peter T. Nelson,H. Brent Clark,Zbigniew K. Wszolek,Dennis W. Dickson,David S. Knopman,Rosa Rademakers +12 more
TL;DR: First genetic and mechanistic evidence that POLD and HDLS are a single clinicopathologic entity is provided.